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NEW YORK, Aug. 21 -- An experimental vaccine aimed at tangles of tau protein, the lesser-known Alzheimer's pathology, slowed deterioration of function and frontotemporal dementia in mice, found investigators here.

When injected into mice bred to develop abnormal tangles of tau protein -- a pathologic hallmark of Alzheimer's dementia along with beta-amyloid plaque -- the vaccine induced antibodies to tau that crossed the blood-brain barrier and reduced the tau burden, reported Einar Sigurdsson, Ph.D., of New York University.

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