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(PSYCHIATRIC TIMES) - MedPage Today Action Points

o Explain to interested patients that this suggests that some symptoms of depression may be associated with the development of atherosclerosis.

o Explain to interested patients that the findings in this report need to be confirmed in other studies and other patient populations.

PITTSBURGH, Feb. 7 -- Common symptoms of depression such as fatigue, sleep disturbances, and anhedonia may trigger initima-media thickness changes associated with subclinical atherosclerosis, researchers here reported.

In a study of 324 healthy older adults, higher depressive symptoms at baseline were significantly associated with greater three-year change in intima-media thickness (?R2 =0.026, P=0.002), found Jesse C. Stewart, Ph.D. of the University of Pittsburgh, and colleagues.

Thickening of the carotid arterial wall was specifically related to somatic-vegetative symptoms (?R2 =0.027, P=0.002), but was not related to anger, hostility, anxiety and other cognitive-affective symptoms, they reported in the February issue of Archives of General Psychiatry.

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