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Protein Panel Could Signal Presence of Alzheimer's Pathology

(PSYCHIATRIC TIMES) - MedPage Today Action Points

o Explain to patients that there is currently no definitive biological test for diagnosing or ruling out the presence of Alzheimer's disease or predicting its onset.

STANFORD, Calif., Oct. 15 -- A way to predict the development of Alzheimer's disease years before its clinical onset has been described by investigators here.

A group of 18 cell-signaling proteins in blood plasma, involved in inflammatory and immune processes, appears to distinguish Alzheimer's from controls with close to 90% accuracy, and could one day offer a predictive diagnostic test, according to its developers.

The experimental protein panel, if verified in additional tests, could also predict which patients with mild cognitive impairment may progress to Alzheimer's-type dementia within six years, reported Tony Wyss-Coray, Ph.D., of Stanford, and colleagues, online in Nature Medicine.

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