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Post-op Delirium More Frequent If Alzheimer's-Linked Allele Present

MedPage Today Action Points

o Explain to patients who ask that postoperative delirium among older patients is a risk factor for discharge to a nursing facility or in-hospital death.

SAN FRANCISCO, Aug. 24 -- Older surgical patients who carry the (ApoE4) allele, a risk factor for early-onset Alzheimer's disease, are an at increased risk for postoperative delirium, according to researchers here.

Among patients over 65 who had major surgery other than cardiac procedures, a quarter of all those who had delirium on the first two postop days had at least one copy of the apolipoprotein (E4 ApoE4) allele, found Jacqueline M. Leung, M.D., M.P.H., of the University of California San Francisco, and colleagues.

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