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Philips aims to develop PET CAD for Alzheimer’s disease

(PSYCHIATRIC TIMES) - Philips Medical Systems is developing software that will optimize and analyze PET brain images for signs of Alzheimer's disease and other forms of dementia. An early version of the prototype will soon be evaluated by researchers at the University Medical Center Hamburg-Eppendorf in Germany, who are working with Philips' scientists to evolve the technology into a clinically useful tool.

Functional and structural brain-scan information has been compiled on the three major neurodegenerative diseases: Alzheimer's disease, Lewy body dementia, and frontotemporal dementia.

The experimental software overlays MR and PET images obtained on the same patient during different exams, postprocesses the data, and applies computer learning techniques to match suspected patterns of disease to those found in the reference database of brain scans indicating dementia.

The ultimate goal is to present fused MR and PET images of patients that can be matched against the reference images so a physician can quickly and effectively compare them.

"Part of a doctor's task when visually evaluating images is to try to classify current images using ones showing disease that he or she has seen previously," said Stewart Young, senior scientist in the digital imaging department of Philips.

The engineers hope their software will be able to more effectively draw from a broader reference base and to display the images instantaneously for assessment by the physician as a way to streamline the process.

Such an automated system could help physicians of varying experience achieve a high level of accuracy in their diagnoses. It might also serve as a research tool in the development and testing of drugs to treat patients with neurodegenerative diseases.

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