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Older Patients with Depression Respond to Augmentation

(PSYCHIATRIC TIMES) - MedPage Today Action Points

o Explain to patients who ask that older adults with depression may benefit from a second medication if the first-line antidepressant doesn't prove adequate, the authors of this study found.

PITTSBURGH, June 1 -- Adding another drug when older patients don't respond well to an initial course of antidepressants may be of benefit, researchers here suggested.

Half of depressed patients age 70 and older who had an inadequate initial response to treatment with a selective serotonin reuptake inhibitor (SSRI) recovered from depression after treatment was augmented with another drug, reported Mary Amanda Dew, Ph.D., and colleagues, of the University of Pittsburgh.

In addition, two-thirds of patients who received augmentation after an early relapse also recovered, the authors wrote in the June issue of the American Journal of Psychiatry.

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