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Inflammatory Cytokines Linked to Alzheimer's Risk

(PSYCHIATRIC TIMES) - MedPage Today Action Points

o Explain to patients who ask that there is conflicting evidence to suggest that inflammation may play a role in the development of Alzheimer's disease.

BOSTON, May 30 -- There's more evidence to support the inflammatory hypothesis of Alzheimer's disease, a finding that emerged from the Framingham Heart study cohort.

Higher levels of inflammatory cytokines produced by peripheral blood cell suggested they are a risk marker for dementia, reported Zaldy S. Tan, M.D., M.P.H., of Harvard, and colleagues, in the May 29 issue of Neurology

In a study of 691 cognitively intact seniors who were part of the Framingham cohort, those in either the middle third of spontaneous production of interleukin 1 (IL-1), and the top third of tumor necrosis factor-? had a more than 2.5-fold risk for incident Alzheimer's,

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