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(PSYCHIATRIC TIMES) - BOSTON, Feb. 7 -- A commonly used general anesthetic creates a vicious cycle of cell death and deposits of Alzheimer's disease proteins -- at least in cell culture.

In laboratory experiments with cultured neuroglioma cells, Florane (isoflurane) was linked to increases in apoptosis as well as generation and aggregation of amyloid-?, whose deposits in the brain are characteristic of Alzheimer's, according to Zhongcong Xie, M.D., Ph.D., of the Massachusetts General Hospital Institute for Neurodegenerative Disease here.

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CMEinfo: Board Reviews in Anesthesia, Cardiology, Internal Medicine, Radiology

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