The articles in this Special Report, although far from comprehensive, address an intriguing sample of the many key topics in child and adolescent psychiatry today. The discussion of the black-box warning applied to SSRIs is a good place to start. We are all trying to practice evidenced-based medicine and yet defining risk/benefit, even with a common condition such as adolescent depression, is no easy task. Black-box warnings are meant to reduce the risk for an individual patient as the physician decides whether to prescribe a specific medication. However, what is the impact of the black box beyond the individual?