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ASCO: No Antidepressant Benefit for Cancer Patients Lacking Major Depression

(PSYCHIATRIC TIMES) - MedPage Today Action Points

o Explain to interested patients that the study suggests cancer patients without an indication for antidepressant treatment should not receive it.

o Explain that the study does not suggest changing clinical practice or indications for the use of antidepressant medication in cancer patients with major depression.

CHICAGO, June 3 -- Unless cancer patients have major depression, antidepressants don't seem to do anything for them, Australian researchers have found.

Sertraline (Zoloft) did not lead to less depression, anxiety, or fatigue, or to a better overall quality of life than did placebo for those with advanced cancer, reported Martin R. Stockler, M.B.B.S., M.Sc., of the University of Sydney in Australia, and colleagues.

These findings of the randomized clinical trial were unexpected and disappointing, Dr. Stockler said at the American Society of Clinical Oncology meeting here.

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