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(PSYCHIATRIC TIMES) - TORONTO, Jan. 15 -- A second gene as a possible accessory in the development of late-onset Alzheimer's disease has been identified by an international team of researchers.

Inherited variants of the gene, called SORL1, short for sortilin-related receptor 1, may be indirectly involved in the abnormal production and deposition in the brain of beta-amyloid plaques, reported the researchers online in Nature Genetics.

"Taken together, our results suggest that genetic and possibly environmentally specified changes in SORL1 expression or function are causally linked to the pathogenesis of Alzheimer disease and have a modest effect on risk for this disease," wrote Peter St. George-Hyslop, M.D., D.Sc., of the University of Toronto, and colleagues.

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