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PsychiatryRounds Psychiatry News's Blog – October 2007 Archive (24)

Protein Panel Could Signal Presence of Alzheimer's Pathology

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients that there is currently no definitive biological test for diagnosing or ruling out the presence of Alzheimer's disease or predicting its onset.



STANFORD, Calif., Oct. 15 -- A way to predict the development of Alzheimer's disease years before its clinical onset has been described by investigators here.



A group of 18 cell-signaling proteins in blood plasma, involved in inflammatory and immune… Continue

Added by psychiatryRounds Psychiatry News on October 15, 2007 at 9:00pm — No Comments

Protein Panel Could Signal Presence of Alzheimer's Pathology

(PSYCHIATRIC TIMES) - STANFORD, Calif., Oct. 15 -- A way to predict the development of Alzheimer's disease years before its clinical onset has been described by investigators here.



A group of 18 cell-signaling proteins in blood plasma, involved in inflammatory and immune processes, appears to distinguish Alzheimer's from controls with close to 90% accuracy, and could one day offer a predictive diagnostic test, according to its developers.



The experimental protein panel, if… Continue

Added by psychiatryRounds Psychiatry News on October 15, 2007 at 9:00pm — No Comments

Schizophrenia Diagnosis Associated with Higher Mortality Rate

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that this study reports increased mortality for people with schizophrenia at a given age, including a 12-fold increase in the suicide rate compared with the general population.



o Explain that people with schizophrenia are less likely to die from stroke than people in the general population and the risk of cancer mortality is only slightly elevated for people with schizophrenia.



o… Continue

Added by psychiatryRounds Psychiatry News on October 5, 2007 at 10:30pm — No Comments

Schizophrenia Diagnosis Associated with Higher Mortality Rate

(PSYCHIATRIC TIMES) - WACOL, Australia, Oct. 5 -- Schizophrenia leads to an age-related mortality rate that is about 2.5 times that of the general population, and the difference appears to be increasing, researchers here reported.



Suicide, which was more than 12 times more likely among people with schizophrenia, was the leading cause-specific mortality risk, John McGrath, M.D., Ph.D., of the Park Center for Mental Health, and colleagues, reported in the October issue of Archives of… Continue

Added by psychiatryRounds Psychiatry News on October 5, 2007 at 10:30pm — No Comments

Donepezil (Aricept) Equals Placebo at Calming Agitation of Alzheimer's

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients that agitation is a common symptom of Alzheimer's disease, and that cholinesterase inhibitors such as donepezil (Aricept) may reduce the rate of cognitive decline in people with Alzheimer's disease, but do not appear to reduce agitation any better than placebo.



LONDON, Oct. 4 -- For treating agitation in Alzheimer's disease, the cholinesterase inhibitor donepezil (Aricept) was no better than placebo,… Continue

Added by psychiatryRounds Psychiatry News on October 4, 2007 at 9:30pm — No Comments

Senator Domenici Has Rare Dementia, Frontotemporal Lobar Degeneration

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients that frontotemporal lobar degeneration and other frontotemporal lobe dementias are rare, accounting for only about 3% of all dementias.



o Explain that frontotemporal dementias may cause drastic personality changes and loss of inhibition that may cause patients to act in appropriate or deeply embarrassing ways in public.



o Explain that there is no known cure or effective therapy against the… Continue

Added by psychiatryRounds Psychiatry News on October 4, 2007 at 9:00pm — No Comments

Donepezil (Aricept) Equals Placebo at Calming Agitation of Alzheimer's

LONDON, Oct. 4 -- For treating agitation in Alzheimer's disease, the cholinesterase inhibitor donepezil (Aricept) was no better than placebo, found a multicenter study.



After a 12-week trial, Alzheimer's patients with clinically significant agitation given 10 mg of donepezil daily had no significant difference in agitation symptoms compared with patients taking placebo, reported Robert J. Howard, M.R.C.Psych., of Kings College London, and colleagues.



"Although previous… Continue

Added by psychiatryRounds Psychiatry News on October 4, 2007 at 9:00pm — No Comments

Personality Trait Linked to Risk of Developing Alzheimer's

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that higher levels of a personality trait called conscientiousness -- being self-disciplined and purposeful -- appeared linked to a decreased risk of developing Alzheimer's disease.



o Point out that conscientiousness was not directly linked to actual brain changes among individuals who died during the study.



CHICAGO, Oct. 2 -- A neat orderly mind augmented by a conscientious… Continue

Added by psychiatryRounds Psychiatry News on October 2, 2007 at 9:30pm — No Comments

Personality Trait Linked to Risk of Developing Alzheimer's

(PSYCHIATRIC TIMES) - CHICAGO, Oct. 2 -- A neat orderly mind augmented by a conscientious personality tends to resist Alzheimer's disease, researchers here found.



Self-disciplined and goal-directed persons who scored high on a standard measure of conscientiousness had an 89% lower risk of developing Alzheimer's than those with low scores, Robert S. Wilson, Ph.D., of Rush University, and colleagues, reported in the October issue of the Archives of General… Continue

Added by psychiatryRounds Psychiatry News on October 2, 2007 at 9:30pm — No Comments

Cognitive Reserve Gets More Backing as Dementia Hedge

(PSYCHIATRIC TIMES) - STOCKHOLM, Oct. 2 -- A healthy cognitive reserve, deposited over a lifetime of learning, appears to protect the better-educated patients from dementia, investigators here suggested.



Among nearly 1,500 adults followed for more than 20 years, those who had at least six years of formal education had a significantly lower risk for any form of dementia and for Alzheimer's disease than adults who had five years of schooling or less, reported Tiia Ngandu, M.D., Ph.D.,… Continue

Added by psychiatryRounds Psychiatry News on October 2, 2007 at 9:30pm — No Comments

Panic Attacks Linked to Cardiovascular Events and Death

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that the study supports a link between panic attacks in postmenopausal women and cardiovascular events and death but cannot show whether the link is causal.



o Consider monitoring cardiovascular risk of postmenopausal women who have had a panic attack.



BOSTON, Oct. 2 -- Panic attacks may be an independent risk factor for cardiovascular events in older women, researchers… Continue

Added by psychiatryRounds Psychiatry News on October 2, 2007 at 5:00am — No Comments

Panic Attacks Linked to Cardiovascular Events and Death

(PSYCHIATRIC TIMES) - BOSTON, Oct. 2 -- Panic attacks may be an independent risk factor for cardiovascular events in older women, researchers said.



Postmenopausal women who reported a panic attack were three times more likely to have a heart attack or stroke over the next five years, according to results of a cohort study reported in the October issue of the Archives of General Psychiatry. They also had nearly twice the risk of all-cause mortality than other… Continue

Added by psychiatryRounds Psychiatry News on October 2, 2007 at 5:00am — No Comments

Treatment of Depression in Adolescents: TADS Results and Future Directions

(PSYCHIATRIC TIMES) - The Treatment for Adolescents With Depression Study (TADS) represents the single largest and potentially most informative clinical trial of adolescents with depressive illness. The overall aim of the study was to investigate the effectiveness of standard interventions for adolescent outpatients with moderate to severe depression. The rationale for the trial, the study design, the clinical characteristics of the sample recruited for the trial, the acute phase treatment… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2007 at 10:00pm — No Comments

Bone Density Loss in Elderly Related to Depression, SSRI Therapy

(PSYCHIATRIC TIMES) - Bone mineral density (BMD) was reduced at a greater rate in older women when they had symptoms of depression, according to one recent report from the Study of Osteoporotic Fractures Research Group, while another report implicated treatment with SSRI antidepressants.



Depressive symptoms rather than antidepressant treatment were associated with this risk factor for osteoporosis in a population-based prospective cohort study involving more than 4000 women aged 69… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2007 at 10:00pm — No Comments

"Postabortion Depression": Clarification from the APA

(PSYCHIATRIC TIMES) - The Washington Report in the July issue of Psychiatric Times ("Postpartum Depression Bill Likely to Move Forward", Psychiatric Times, July 2007) described the Melanie Blocker-Stokes Postpartum Depression Research and Care Act (HR 20), which was introduced by Rep Bobby Rush (D, Ill). I testified in support of this important bill at the committee hearing on behalf of the American Psychiatric Association (APA).



Although the Washington Report used the term… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2007 at 10:00pm — No Comments

Pick Disease: Navigating the Frontotemporal Dementia Diagnosis

(PSYCHIATRIC TIMES) - The clinical diagnosis of Pick disease can be one of the most difficult facing the neurologist. Those patients found to have lobar atrophy usually present clinically with bouts of irrational behavior, bulimia, marked reductions in speech, abulia, and apathy.



In contrast with Alzheimer disease (AD), Pick disease generally is not associated with symptoms of memory loss or disorientation in regard to time and space. Aphasia is a prominent feature. Psychiatric… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2007 at 9:30pm — No Comments

Atypical Antipsychotics for Dementia-Related Behaviors

(PSYCHIATRIC TIMES) - Antipsychotic drugs have been the primary psychopharmacological mainstay of treatment for psychosis, agitation, and aggression in Alzheimer Disease (AD) and other dementias.



Conventional antipsychotic drugs such as haloperidol have been supplanted by newer, atypical antipsychotics (risperidone [Risperdal], olanzapine [Zyprexa], quetiapine [Seroquel], ziprasidone [Geodon], aripiprazole [Abilify]), although no medication has an FDA indication for the treatment of… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2007 at 9:30pm — No Comments

AIDS Dementia: Current Status and New Treatment Approaches

(PSYCHIATRIC TIMES) - In the long list of morbidities associated with HIV-1 infection, the most common neurodegenerative disorder is HIV-associated dementia (HAD).1 Symptoms are classic signs of cognitive impairment: confusion, forgetfulness, slowed thinking, and poor concentration. Behavioral changes include dysphoria, reduced emotional responsiveness, social withdrawal, and apathy. Psychiatric symptoms resembling those seen in severe psychiatric disorders—severe agitation, delusions, and… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2007 at 9:30pm — No Comments

Cognitive Complaints: Their Role in Detecting MCI and Dementia

Dementia, of which Alzheimer disease (AD) is the most common cause, is a major health problem confronting contemporary society. Because prompt (and, in the future, possibly preclinical) initiation of treatment offers the greatest hope for the successful management of AD, early diagnosis is essential.



Short of mass screening of the elderly using a neuropsychological test or some yet-to-be-determined biomarker, persons with cognitive disorders come to the attention of the health care… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2007 at 9:30pm — No Comments

Recognition of Apathy as Marker for Dementia Growing

(PSYCHIATRIC TIMES) - “People are getting excited about apathy now because it may be a behavioral marker for a more rapidly progressing dementia,” said Prasad Padala, MD, assistant professor of psychiatry at the University of Nebraska Medical Center in Omaha.



A recent 4-year study linked apathy to a hastened decline in persons with Alzheimer disease (AD).1 Another recent study found that persons with mild cognitive impairment (MCI) were more likely to convert to AD a year later if… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2007 at 9:30pm — No Comments

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