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PsychiatryRounds Psychiatry News's Blog – October 2005 Archive (10)

Signals * promising developments for neurology

(PSYCHIATRIC TIMES) - Are Errant Astrocytes the Cause and Therapeutic Target of Epilepsy?



Targeting astrocytes instead of symptoms may become a new strategy for managing--and perhaps curing--epilepsy. Indeed, researchers from the University of Rochester in New York demonstrated that common antiepileptic agents--gabapentin (Neurontin, Pfizer), phenytoin, and valproate--"potently reduce" astrocytic calcium signaling. Their research illustrated how such signaling, which mediates… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2005 at 8:30pm — No Comments

Neuronal Plasticity and Mood Disorders

(PSYCHIATRIC TIMES) - The ability to adapt to changing environmental conditions is the most fundamental feature of the nervous system. At the neurobiological level, this adaptation corresponds to neuronal plasticity, defined as the lifelong ability of the brain to reorganize neural pathways based on new experiences. Reorganization is robust during early postnatal development and declines thereafter, but experiences shape neuronal networks to a more limited extent in the adult brain as well… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2005 at 8:30pm — No Comments

The Light-er Side of Treating Seasonal Affective Disorder

(PSYCHIATRIC TIMES) - Rosenthal et al. (1984) first described seasonal affective disorder (SAD) as a pattern of recurrent depressions with a winter onset and a full remission the following summer. The emergence of treatment, specifically light therapy, was met with a mixture of enthusiasm and cautious skepticism. However, there is now substantial evidence to support its efficacy. This paper will review the treatment of SAD with a focus on new developments in the area.



The clinical… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2005 at 5:30am — No Comments

Impact of ECT on Health-Related Quality of Life and Function in Patients With Depression

(PSYCHIATRIC TIMES) - Health-related quality of life (HRQOL) can be defined as a broad array of outcomes that go beyond syndrome-specific symptoms or mortality and can include satisfaction and competence in primary life role (e.g., student, homemaker or breadwinner), satisfaction and competence in relationships, freedom from pain and mental anguish, energy, and other broad and subjective psychosocial constructs affected by one's health. Health-related quality of life is part of the larger… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2005 at 3:30am — No Comments

Where Research Paths Converge: Improving Treatments for Depression

(PSYCHIATRIC TIMES) - During the past three decades, more research has been conducted on depression than on any other psychiatric disorder. The clinical and public health significance of depression was heightened by the results of the Medical Outcomes Study, which demonstrated that depression was more impairing than other chronic medical disorders such as arthritis and diabetes, and as impairing as cardiovascular disease (Wells et al., 1989). Recently, the replication of the National… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2005 at 2:00am — No Comments

Depression, Stress and the Risk of Heart Disease

(PSYCHIATRIC TIMES) - In recent years, depression has emerged in the discussion of the impact of psychological aspects on risk of heart disease. Several prognostic studies have shown that depression is a predictor for mortality after acute myocardial infarction (AMI) (Frasure-Smith et al., 1995a, 1993) and the risk is directly related to the severity of mood symptoms: a one- to twofold increase in coronary heart disease (CHD) for minor depression and a three- to fivefold increase for major… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2005 at 2:00am — No Comments

Family Therapy in the Treatment of Depression

(PSYCHIATRIC TIMES) - The current most commonly used model for the understanding and treatment of depression is a biomedical one that emphasizes symptom resolution. The mainstay of contemporary psychiatric treatment is pharmacotherapy, and of contemporary psychological treatment, cognitive-behavioral therapy. Both pharmacotherapy and psychotherapy can be effective treatments for depression, but, in spite of their efficacy, a significant minority of patients with depression do not respond well… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2005 at 2:00am — No Comments

Testosterone Deficiency, Depression and Sexual Function in Aging Men

(PSYCHIATRIC TIMES) - Educational Objectives:



Upon completion of this educational activity, the reader will be familiar with:



* The complex psychobiology of the hypothalamic-pituitary-gonadal axis, particularly as it relates to male sexual and affective disorders.

* The growing epidemiologic and clinical data that confirm progressive HPG hypofunctioning in aging men.

* The treatment rationale, clinical indications and risks in using exogenous testosterone for… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2005 at 2:00am — No Comments

Testosterone Deficiency, Depression and Sexual Function in Aging Men

(PSYCHIATRIC TIMES) - Educational Objectives:



Upon completion of this educational activity, the reader will be familiar with:



* The complex psychobiology of the hypothalamic-pituitary-gonadal axis, particularly as it relates to male sexual and affective disorders.

* The growing epidemiologic and clinical data that confirm progressive HPG hypofunctioning in aging men.

* The treatment rationale, clinical indications and risks in using exogenous testosterone for… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2005 at 2:00am — No Comments

Understanding the Role of Sigma-1 Receptors in Psychotic Depression

(PSYCHIATRIC TIMES) - Psychosis occurs in 10% to 37.1% of patients with mood disorders (Johnson et al., 1991; Thakur et al., 1999). Psychotic depression is a clinical subtype of major depressive disorder and is characterized by psychosis accompanied by greater severity of depressive symptoms that include psychomotor impairment (retardation or agitation), morbid cognition (involving guilt and a sense of deserving punishment), suicidal idea and neuropsychological impairment (Jeste et al., 1996).… Continue

Added by psychiatryRounds Psychiatry News on October 1, 2005 at 2:00am — No Comments

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