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October 2006 News and Blog Posts (33)

Treatment-Resistant Anxiety Disorders: Neurotrophic Perspectives

(PSYCHIATRIC TIMES) - Anxiety disorders are the most prevalent psychiatric disorders in the United States. Although effective treatments are available, such as the SSRIs and cognitive-behavioral therapy (CBT), it is estimated that in about 40% of patients, anxiety disorders are partially or completely resistant to first-line treatment.1 The underlying causes of such high rates of treatment resistance are unclear, but these patients are likely to pose a major challenge for psychiatrists, since… Continue

Added by psychiatryRounds Psychiatry News on October 31, 2006 at 5:30am — No Comments

AACAP: Investigational Pediatric ADHD Agent Aims at Reduced Abuse Potential

(PSYCHIATRIC TIMES) - MedPage Today Action Points



SAN DIEGO, Oct. 31 -- An investigational d-amphetamine prodrug appears to be effective in treating pediatric attention deficit hyperactivity disorder, with the goal of less abuse potential than amphetamines, researchers said.



All dose levels of lisdexamfetamine (NRP104) were significantly more effective than placebo, said Robert. L. Findling, M.D., of Case Western Reserve in Cleveland, and colleagues, who presented the… Continue

Added by psychiatryRounds Psychiatry News on October 31, 2006 at 3:00am — No Comments

Augmentation Strategies in Treatment-Resistant Depression

(PSYCHIATRIC TIMES) - The treatment of unipolar major depression presents a substantial challenge for the clinician. Major depression is a common disorder1 with a high propensity for relapse and recurrence.2 In addition, it is increasingly evident that antidepressant treatment offers moderate benefits and that sequential treatments are invariably required to obtain a satisfactory therapeutic effect.



Recent research findings confirm earlier observations that about 50% of patients with… Continue

Added by psychiatryRounds Psychiatry News on October 30, 2006 at 11:00pm — No Comments

Treatment Resistance in Schizophrenia: The Role of Alternative Therapies

(PSYCHIATRIC TIMES) - In 1931, Gananath Sen and Kartick Chandra Bose1 reported on the use of an alkaloid extract from the Rauwolfia serpentina plant in the treatment of hypertension and "insanity with violent maniacal symptoms." They noted that dosages "of 20 to 30 grains of the powder twice daily produce not only a hypnotic effect but also a reduction of blood pressure and violent symptoms . . . within a week usually the patient's senses are restored, though he may show some mental… Continue

Added by psychiatryRounds Psychiatry News on October 30, 2006 at 11:00pm — No Comments

Pathology and Management of Treatment Resistance in Bipolar Disorder

(PSYCHIATRIC TIMES) - The problem of treatment resistance in bipolar disorder begins with its definition. Characterizing the phases of bipolar disorder as manic, mixed, hypomanic, or depressed does not do justice to the reality for many persons with this disorder. Persistent symptoms of mood elevation, irritability, and depression are all too common in the short- and long-term course of mood episodes with this illness; return to complete euthymia is rare, and recurrence and relapse are the rule… Continue

Added by psychiatryRounds Psychiatry News on October 30, 2006 at 4:30am — No Comments

Pathology and Management of Treatment Resistance in Bipolar Disorder

(PSYCHIATRIC TIMES) - The problem of treatment resistance in bipolar disorder begins with its definition. Characterizing the phases of bipolar disorder as manic, mixed, hypomanic, or depressed does not do justice to the reality for many persons with this disorder. Persistent symptoms of mood elevation, irritability, and depression are all too common in the short- and long-term course of mood episodes with this illness; return to complete euthymia is rare, and recurrence and relapse are the rule… Continue

Added by psychiatryRounds Psychiatry News on October 30, 2006 at 4:00am — No Comments

AACAP: Vitamin B12 Injections for Autism Show No Signs of Benefit

(PSYCHIATRIC TIMES) - MedPage Today Action Points



SAN DIEGO, Oct. 30 -- Preliminary results of a small ongoing study of vitamin B12 injections for children with autism showed no signs of significant benefit, researchers reported here, but they remained hopeful.



So said Lesley J. Deprey, Ph.D., of the University of California at Davis, and colleagues, in a poster presentation at the American Academy of Child and Adolescent Psychiatry meeting here.



Their hope,… Continue

Added by psychiatryRounds Psychiatry News on October 30, 2006 at 3:30am — No Comments

AACAP: Growth Reduction Seen Temporary for Children on ADHD Drug

(PSYCHIATRIC TIMES) - MedPage Today Action Points



SAN DIEGO, Calif., Oct. 30 -- Strattera (atomoxetine) given to children with attention deficit hyperactivity disorder does not appear to stunt growth over the long term, according to a lengthy study.



Height, weight and body mass index (BMI) percentiles dropped initially with Strattera treatment but returned to pretreatment levels after three years of continual therapy, said Thomas J. Spencer, M.D., of Massachusetts General… Continue

Added by psychiatryRounds Psychiatry News on October 30, 2006 at 3:00am — No Comments

AACAP: With Anorexia, Obsessions and Compulsions Have Limits

(PSYCHIATRIC TIMES) - SAN DIEGO, Oct. 27 -- Although anorexia nervosa patients commonly have obsessions and compulsions, that doesn't necessarily translate into full-blown obsessive-compulsive disorder, according to a Polish team.



In a study of 120 adolescent patients with anorexia, 51.8% had obsessions related to food and body-image and 36.8% had other compulsions, but none met the criteria for obsessive-compulsive disorder, said Tomasz Wolanczyk, M.D., Ph.D., of the Medical… Continue

Added by psychiatryRounds Psychiatry News on October 27, 2006 at 4:00am — No Comments

AACAP: Not Treating Depression During Pregnancy Affects Baby

(PSYCHIATRIC TIMES) - MedPage Today Action Points



SAN DIEGO, Calif., Oct. 26 -- Although antidepressants may have an effect on fetuses in utero, so may the lack of the drug during pregnancy.



Babies born to women with untreated major depressive disorder had significant changes in neurobehavioral function, were born at an earlier gestational age, and had elevated stress hormones, according to a small study reported at the American Academy of Child and Adolescent Psychiatry… Continue

Added by psychiatryRounds Psychiatry News on October 26, 2006 at 11:30pm — No Comments

SFN: Going to Pot May Lower Alzheimer's Risk

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Caution that the research was done in rats and the effects have not been demonstrated in humans.



o This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be preliminary as they have not yet been reviewed and published in a peer-reviewed publication.



ATLANTA, Oct. 19 -- Those years of pot smoking a generation ago may have created an… Continue

Added by psychiatryRounds Psychiatry News on October 19, 2006 at 11:00pm — No Comments

SFN: Going to Pot May Lower Alzheimer's Risk

(PSYCHIATRIC TIMES) - ATLANTA, Oct. 19 -- Those years of pot smoking a generation ago may have created an unexpected legacy for baby boomers -- a lower risk of Alzheimer's disease.



That's the implication of animal research presented by Gary Wenk, Ph.D., of Ohio State University in Columbus at the Society for Neuroscience meeting here.



For full article, please visit:…

Continue

Added by psychiatryRounds Psychiatry News on October 19, 2006 at 11:00pm — No Comments

Behavioral Therapy Said to Treat Kids' Compulsive Disorder Best

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients that this study reinforces current opinions on behavioral therapy.



o Note that behavioral therapy is recommended as the treatment of choice for pediatric obsessive-compulsive disorder by the American Academy of Child and Adolescent Psychiatry.



CANBERRA, Australia, Oct. 19 -- Behavioral or cognitive behavioral therapy, with or without medication, is the top choice against obsessive-compulsive… Continue

Added by psychiatryRounds Psychiatry News on October 19, 2006 at 9:00pm — No Comments

Aricept (donepezil) Wins Indication for Severe Alzheimer's

(PSYCHIATRIC TIMES) - MedPage Today Action Points



ROCKVILLE, Md., Oct. 13 -- Aricept (donepezil), a cholinesterase inhibitor on the market for mild to moderate Alzheimer's disease, today became the first of its class to win FDA approval for severe disease.



The FDA action made Aricept the only drug approved to treat all stages of Alzheimer's.



The FDA decision was based on efficacy demonstrated in two randomized, placebo-controlled 24-week trials in Sweden and… Continue

Added by psychiatryRounds Psychiatry News on October 13, 2006 at 11:00pm — No Comments

Aricept (donepezil) Wins Indication for Severe Alzheimer's

(PSYCHIATRIC TIMES) - ROCKVILLE, Md., Oct. 13 -- Aricept (donepezil), a cholinesterase inhibitor on the market for mild to moderate Alzheimer's disease, today became the first of its class to win FDA approval for severe disease.



The FDA action made Aricept the only drug approved to treat all stages of Alzheimer's.



The FDA decision was based on efficacy demonstrated in two randomized, placebo-controlled 24-week trials in Sweden and Japan. The trials enrolled more than 500… Continue

Added by psychiatryRounds Psychiatry News on October 13, 2006 at 11:00pm — No Comments

Atypical Antipsychotics Get Poor Grade for Alzheimer's Psychoses

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients that agitation, aggression, delusions, hallucinations, and other forms of psychosis are common in patients with more advanced stages of Alzheimer's disease.



o Explain that two of three second-generation antipsychotic drugs do not appear to control psychosis in patients with Alzheimer's disease, and are not approved by the FDA for this indication.



o Point out that because of adverse side… Continue

Added by psychiatryRounds Psychiatry News on October 11, 2006 at 11:00pm — No Comments

Atypical Antipsychotics Get Poor Grade for Alzheimer's Psychoses

(PSYCHIATRIC TIMES) - LOS ANGELES, Oct. 11 -- Two of three atypical antipsychotic drugs were no better than placebo at quieting aggression, psychosis, and agitation in patients with Alzheimer's disease, found a multicenter trial.



Overall, the adverse effects of all three outweighed the benefits, Lon S. Schneider, M.D., of the University of Southern California, and colleagues, reported in the Oct. 12 issue of the New England Journal of Medicine. In the study of more than 400 such… Continue

Added by psychiatryRounds Psychiatry News on October 11, 2006 at 11:00pm — No Comments

Food for Thought for Alzheimer's Emerges in Mediterranean Diet

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that the Mediterranean diet, which showed a decreased Alzheimer's risk in this study, has also been associated with lower risks for cardiovascular disease, several forms of cancer, and overall mortality.



NEW YORK, Oct. 9 -- A Mediterranean-style diet -- spare on red meat and heavy on fruits, vegetables, and olive oil -- may help to fend off Alzheimer's disease, according to researchers… Continue

Added by psychiatryRounds Psychiatry News on October 9, 2006 at 11:30pm — No Comments

Food for Thought for Alzheimer's Emerges in Mediterranean Diet

(PSYCHIATRIC TIMES) - NEW YORK, Oct. 9 -- A Mediterranean-style diet -- spare on red meat and heavy on fruits, vegetables, and olive oil -- may help to fend off Alzheimer's disease, according to researchers here.



The effect was strongest in people who followed a Mediterranean-type diet most religiously, reported Nikolaos Scarmeas, M.D., of Columbia University, and colleagues, in an early online release from the December issue of Archives of Neurology.



Also, the effect… Continue

Added by psychiatryRounds Psychiatry News on October 9, 2006 at 11:30pm — No Comments

Optical technology could lead to screening test for Alzheimer’s

(PSYCHIATRIC TIMES) - Laser-based eye tests now in clinical trials for detection of Alzheimer's disease have proven successful in spotting early molecular signs of the disease. The commercialization of these tests could ignite future demand for imaging studies of patients suspected of Alzheimer's.



The optical technology, which has completed phase I clinical studies and is slated next year to enter phase III, could cost as little as $300, low enough to prompt widespread screening,… Continue

Added by psychiatryRounds Psychiatry News on October 9, 2006 at 11:00pm — No Comments

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