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September 2007 News and Blog Posts (31)

Depression Common Before, During, and After Pregnancy

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that the lifetime risk of depression is about 10%, but women are known to have slightly higher risk than men. This study suggests that the risk of depression is not mitigated by pregnancy.



o Point out that this study supports the position that women considering pregnancy as well as pregnant women and postpartum women should be screened for depressive symptoms.



OAKLAND, Calif.,… Continue

Added by psychiatryRounds Psychiatry News on September 28, 2007 at 10:00pm — No Comments

Autism Symptoms May Improve Over Time for Some

(PSYCHIATRIC TIMES) - MADISON, Wis., Sept. 27 -- Symptoms of autism, including maladaptive behaviors and impaired social interactions, appear to lessen over time in a significant percentage of patients.



In a study of 241 adolescents and adults here and in Massachusetts with autism spectrum disorders, who were followed for nearly five years, many had stable symptoms, but a greater percentage had declines in their levels of autistic symptoms, reported Paul T. Shattuck, Ph.D., M.S.S.W.,… Continue

Added by psychiatryRounds Psychiatry News on September 27, 2007 at 3:30am — No Comments

Depression Management by Phone Called Win-Win

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients that the telephone based care management system described here provided recommendations to clinicians and encouraged patients to seek treatment for depression, but treatment choices were left up to clinicians and patients.



BETHESDA, Md., Sept. 25 -- An aggressive workplace program for identifying and treating depression is both good medical practice and good business, investigators here… Continue

Added by psychiatryRounds Psychiatry News on September 25, 2007 at 10:00pm — No Comments

Depression Management by Phone Called Win-Win

(PSYCHIATRIC TIMES) - BETHESDA, Md., Sept. 25 -- An aggressive workplace program for identifying and treating depression is both good medical practice and good business, investigators here said.



Depressed workers randomized to a managed care plan emphasizing screening, telephone-based outreach, and care management had lower symptoms scores, were more likely to stay on the job, and worked about two weeks more per year than those given usual services, reported Philip S. Wang, M.D.,… Continue

Added by psychiatryRounds Psychiatry News on September 25, 2007 at 10:00pm — No Comments

Brain Deactivation May Be MRI Marker of Early Alzheimer's

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients that this study suggests one possible means for early detection of Alzheimer's disease, but the accuracy of the technique needs to be verified in larger studies.



CHAPEL HILL, N.C., Sept. 25 -- A sensitive sign of the early stages of Alzheimer's disease may be dampening of activity in the posteromedial cortices during a memory task, as seen by functional MRI, investigators here suggested.



In… Continue

Added by psychiatryRounds Psychiatry News on September 25, 2007 at 9:30pm — No Comments

Brain Deactivation May Be MRI Marker of Early Alzheimer's

CHAPEL HILL, N.C., Sept. 25 -- A sensitive sign of the early stages of Alzheimer's disease may be dampening of activity in the posteromedial cortices during a memory task, as seen by functional MRI, investigators here suggested.



In a study comparing functional MRI scans of healthy volunteers with those of patients with mild cognitive impairment or mild Alzheimer's disease, the degree of activation of the posteromedial cortices correlated significantly with scores on a verbal learning… Continue

Added by psychiatryRounds Psychiatry News on September 25, 2007 at 9:30pm — No Comments

EASD: Studies Link Depression and Type 2 Diabetes

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients that it is not known whether type 2 diabetes causes mental health disorders or if they are co-morbidities.



o These studies were published as abstracts and presented at a conference. These data and conclusions should be considered to be preliminary as they have not yet been reviewed and published in a peer-reviewed publication.



AMSTERDAM, Sept. 21 -- Type 2 diabetes may be linked to mental… Continue

Added by psychiatryRounds Psychiatry News on September 21, 2007 at 10:00pm — No Comments

Adherence to Treatment Regimens in Major Depression: Perspectives, Problems, and Progress

(PSYCHIATRIC TIMES) - Adherence, in a medical context, refers to the degree to which a patient follows the treatment plan that has been agreed on between the prescriber (usually, but not always, a physician) and the patient. Although the term "compliance" is often used by caregivers, it is a less desirable term than "adherence," because it implies an all-or-nothing obedience to the will of others. Adherence, like a religious belief, involves recognition that there may be aspects that are less… Continue

Added by psychiatryRounds Psychiatry News on September 15, 2007 at 10:30pm — No Comments

Clinical Depression: Complexities of Diagnosis and Management

(PSYCHIATRIC TIMES) - Major depression is at once simple and complex. At one level, the treatment of this disorder is straightforward. Yet, at a multitude of other levels, it is a complex condition for which available treatments remain suboptimal. Ongoing clinical and translational research in the biology, treatment, and outcome of depression has continued to enlighten the management of this common human affliction. The articles in this special issue highlight the state of the art of depression… Continue

Added by psychiatryRounds Psychiatry News on September 15, 2007 at 10:00pm — No Comments

Never-Ending Winter: Chronic Depression

(PSYCHIATRIC TIMES) - Mood disorders are among the most prevalent forms of mental illness. Serious depression is especially common; based on a face-to-face survey conducted from December 2001 to December 2002, the past-year prevalence rate of clinically significant major depressive disorder (MDD) was estimated to be 6.6%, affecting at least 13.1 to 14.2 million Americans.1 Although many patients with recurrent episodes of illness have good symptom remission between episodes, with few residual… Continue

Added by psychiatryRounds Psychiatry News on September 15, 2007 at 10:00pm — No Comments

Placebo Effects on Pharmacotherapy Outcomes in Major Depression

(PSYCHIATRIC TIMES) - If clinical trials data are any indication, the potential impact of placebo treatment on depression outcomes may be potent. Placebo response rates in clinical trials for depression average approximately 30%, with a top range beyond 50%—and the trend is upward.1 Granted, estimates of the magnitude of the placebo response are open to debate2,3 because placebo response rates do not account for statistical regression to the mean or spontaneous remission (an important… Continue

Added by psychiatryRounds Psychiatry News on September 15, 2007 at 10:00pm — No Comments

Cognitive Therapy: What Is Its Role in Depression Treatment?

(PSYCHIATRIC TIMES) - Although cognitive therapy (CT)1 is the best-studied form of psychotherapy, its effectivenes compared with antidepressant medication remains controversial. Over the years, there has been some variability in the results of randomized controlled trials and other types of clinical trials, as well as meta-analyses. A review of the findings of the STAR*D trial may help shed more light on this important treatment issue.2

Historical clinical studies



Efforts to… Continue

Added by psychiatryRounds Psychiatry News on September 15, 2007 at 10:00pm — No Comments

The Substance Abuse Handbook

(PSYCHIATRIC TIMES) - The Substance Abuse Handbook offers a comprehensive, clinically oriented approach to the treatment of addictive disorders. It contains a wealth of useful information, ranging from causes of addiction to different modes of treatment. The authors' stated goal was ambitious: "We wanted to offer the field the most authoritative, clinically oriented information on the subject of substance use, abuse, and dependence, with emphasis on diagnosis, treatment, and prevention."… Continue

Added by psychiatryRounds Psychiatry News on September 15, 2007 at 1:30am — No Comments

Breast Cancer Drug Tames Acute Mania in Bipolar Disorder

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that the findings for tamoxifen and mania in this small, short, pilot study must still be replicated in a large controlled trial.



BETHESDA, Md., Sept. 12 -- Tamoxifen significantly decreased symptoms of acute mania beginning as early as five days in patients with bipolar disorder in a small pilot study.



The drug, approved to treat breast cancer, maintained its effect throughout a… Continue

Added by psychiatryRounds Psychiatry News on September 12, 2007 at 3:30am — No Comments

Breast Cancer Drug Tames Acute Mania in Bipolar Disorder

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that the findings for tamoxifen and mania in this small, short, pilot study must still be replicated in a large controlled trial.



BETHESDA, Md., Sept. 12 -- Tamoxifen significantly decreased symptoms of acute mania beginning as early as five days in patients with bipolar disorder in a small pilot study.



The drug, approved to treat breast cancer, maintained its effect throughout a… Continue

Added by psychiatryRounds Psychiatry News on September 12, 2007 at 3:30am — No Comments

Breast Cancer Drug Tames Acute Mania in Bipolar Disorder

(PSYCHIATRIC TIMES) - BETHESDA, Md., Sept. 12 -- Tamoxifen significantly decreased symptoms of acute mania beginning as early as five days in patients with bipolar disorder in a small pilot study.



The drug, approved to treat breast cancer, maintained its effect throughout a three-week trial with a response rate of 63% for tamoxifen versus 13% for placebo, Carlos A. Zarate, Jr., M.D., of the National Institute of Mental Health, and colleagues reported online in the Sept. issue of… Continue

Added by psychiatryRounds Psychiatry News on September 12, 2007 at 3:30am — No Comments

Decline in Platelet Count Precedes Onset of HIV Dementia

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients the HIV-related dementia accounts for about 5% of all AIDS-defining illnesses in the U.S., so that understanding its pathogenesis remains important.



o Note that this study suggests that a sharp decline in platelet counts precedes the appearance of dementia by about six months to a year.



BALTIMORE, Sept. 11 -- The development of HIV-related dementia within the ensuing six or 12… Continue

Added by psychiatryRounds Psychiatry News on September 11, 2007 at 9:30pm — No Comments

Decline in Platelet Count Precedes Onset of HIV Dementia

(PSYCHIATRIC TIMES) - BALTIMORE, Sept. 11 -- The development of HIV-related dementia within the ensuing six or 12 months appears to be signaled by a sharp decline in platelet count.



The finding, from a prospective cohort study of 146 HIV patients, offers an easily measured marker for HIV dementia, which accounts for about 5% of AIDS-defining illnesses in the U.S., reported Lynn Wachtman, D.V.M., of Johns Hopkins, and colleagues, in the September issue of Archives of… Continue

Added by psychiatryRounds Psychiatry News on September 11, 2007 at 9:30pm — No Comments

SSRI Comparable to Antipsychotic for Psychosis in Dementia

(PSYCHIATRIC TIMES) - TORONTO, Sept. 10 -- An antidepressant may be just as effective as an antipsychotic for calming agitation and treating psychotic symptoms in older patients with dementia, investigators here reported.In a small study comparing the selective serotonin reuptake inhibitor citalopram (Celexa) with the antipsychotic risperdone (Risperdal), the efficacy of the SSRI was comparable at relieving psychotic symptoms, with fewer adverse events, reported Bruce G. Pollock, M.D., Ph.D.,… Continue

Added by psychiatryRounds Psychiatry News on September 10, 2007 at 9:30pm — No Comments

Mediterranean Diet May Prolong Life of Alzheimer's Patients

NEW YORK, Sept. 10 -- The so-called Mediterranean diet appears to lower mortality among Alzheimer's patients, with a possible dose-response effect, researchers reported.



In the study's highest tertile, adherence to the Mediterranean diet produced a 73% mortality risk reduction, leading to an average survival of nearly four years longer than those in the lowest tertile of adherence, Nikolaos Scarmeas, M.D., of Columbia University here, and colleagues reported in the Sept. 11 issue of… Continue

Added by psychiatryRounds Psychiatry News on September 10, 2007 at 9:30pm — No Comments

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