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July 2006 News and Blog Posts (38)

Carotid Stenting Relieves 'Vascular Depression'

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Advise patients who ask that this study suggests that high-grade carotid stenosis is associated with apparently reversible depressive symptoms. Note that in this study more than a third of patients had such symptoms, compared with less than 17% in patients without stenosed carotids.



VIENNA, July 25 -- Carotid stenting can significantly ease both the frequency and severity of so-called "vascular depression," according to… Continue

Added by psychiatryRounds Psychiatry News on July 25, 2006 at 1:00am — No Comments

Carotid Stenting Relieves 'Vascular Depression'

(PSYCHIATRIC TIMES) - VIENNA, July 25 -- Carotid stenting can significantly ease both the frequency and severity of so-called "vascular depression," according to investigators here.



Both frequency and severity" fell sharply in patients who underwent successful carotid stenting for a luminal narrowing of at least 80%, according to Wolfgang Mlekusch, M.D., of Vienna General Hospital and Medical School here.



At the same time, neither frequency nor severity of depression… Continue

Added by psychiatryRounds Psychiatry News on July 25, 2006 at 1:00am — No Comments

High Estrogen Levels Linked to Dementia in Elderly Men

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that the increased levels of estradiol in these men in this study may be a consequence of an earlier marker for Alzheimer's rather than the cause of the disease.



o Be aware that testosterone levels in elderly men did not affect cognitive decline or the risk of Alzheimer's disease.



o Note that testosterone replacement therapy is not recommended for healthy older… Continue

Added by psychiatryRounds Psychiatry News on July 24, 2006 at 1:00am — No Comments

High Estrogen Levels Linked to Dementia in Elderly Men

(PSYCHIATRIC TIMES) - UTRECHT, The Netherlands, July 24 -- For men ages 70 to 91, Alzheimer's disease and other dementias have been associated with high levels of endogenous estrogen, but not high levels of testosterone, researchers here reported.



The retrospective analysis of the role of endogenous hormones in elderly men emerged from analysis of data in the prospective cohort of 2,974 Japanese-American men, ages 71 to 91, in the Honolulu-Asia Aging Study. The men were dementia-free… Continue

Added by psychiatryRounds Psychiatry News on July 24, 2006 at 1:00am — No Comments

ICAD: GnRH Gets Renewed Chance for Alzheimer's Patients

MedPage Today Action Points



o Note that the drug being used for Alzheimer's disease is a proprietary formulation of leuprolide.



o Explain to patients that the study is a Phase II trial that has not yet been published nor undergone peer review process.



o Also note that the results of the Phase II study were far from definitive and that further studies may be needed before treatment with the drug should be tried.



o This study was published as an… Continue

Added by psychiatryRounds Psychiatry News on July 20, 2006 at 1:30am — No Comments

ICAD: Patch Smoothes Alzheimer's Drug Delivery

MedPage Today Action Points



o Explain to interested patients and caregivers that the transdermal patch for Alzheimer's disease is still an investigational drug that has not been approved by the FDA.



o This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be preliminary as they have not yet been reviewed and published in a peer-reviewed publication.



MADRID, July 20 -- An investigational… Continue

Added by psychiatryRounds Psychiatry News on July 20, 2006 at 1:30am — No Comments

ICAD: GnRH Gets Renewed Chance for Alzheimer's Patients

(PSYCHIATRIC TIMES) - MADRID, July 20 -- When it comes to therapy for Alzheimer's disease, if a phase II trial isn't all that's expected, try a phase III.



That seems to be the philosophy of Voyager Pharmaceutical of Raleigh, N.C., which reported at the International Conference on Alzheimer's Disease and Related Disorders here that it is moving ahead with phase III trials of a proprietary formulation of leuprolide, the GnRH analog, despite mixed findings in a phase II clinical trial… Continue

Added by psychiatryRounds Psychiatry News on July 20, 2006 at 1:30am — No Comments

ICAD: Patch Smoothes Alzheimer's Drug Delivery

(PSYCHIATRIC TIMES) - MADRID, July 20 -- An investigational transdermal patch to deliver an Alzheimer's drug appears to be as effective as currently marketed Exelon (rivastigmine) capsules and eases compliance worries, researchers said here.



"The rivastigmine patch provides similar efficacy to the highest capsule doses, and was superior to placebo," said Bengt Winblad, MD, of Karolinska Institute in Stockholm reported at the at the International Conference on Alzheimer's Disease and… Continue

Added by psychiatryRounds Psychiatry News on July 20, 2006 at 1:00am — No Comments

ICAD: Lung Function Deficiency Tied to Dementia Risk

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that this observational study suggests that lung function may be a predictor of the risk of the future development of dementia.



o This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be preliminary as they have not yet been reviewed and published in a peer-reviewed publication.



MADRID, July 18 -- Lung… Continue

Added by psychiatryRounds Psychiatry News on July 18, 2006 at 1:30am — No Comments

ICAD: Lung Function Deficiency Tied to Dementia Risk

(PSYCHIATRIC TIMES) - MADRID, July 18 -- Lung function of Medicare-age patients, as measured by standard spirometry, can suggest how likely they are to develop dementia in the next five to six years, researchers reported here.



Lung capacity tests were performed with patients, all 65 or older, who were followed prospectively for more than five years before they were examined again and their dementia status was assessed, said a Seattle team.



Dementia in this study was… Continue

Added by psychiatryRounds Psychiatry News on July 18, 2006 at 1:30am — No Comments

DBS Curbs Major Depression and OCD

(PSYCHIATRIC TIMES) - Deep brain stimulation (DBS) may hold promise for patients with treatment-resistant and severe major depression and obsessive-compulsive disorder (OCD). However, it may not be the best choice for patients with Parkinson (PD) disease who display certain compulsive behaviors, reported researchers from the Cleveland Clinic and from Brown Medical School (Providence, Rhode Island) at the annual meeting of the American Academy of Neurological Surgeons, which took place April… Continue

Added by psychiatryRounds Psychiatry News on July 17, 2006 at 9:00pm — No Comments

ICAD: Risk Factors Total a Score to Predict Dementia Risk

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients that the dementia risk score suggests that there is a link between cardiovascular health and dementia.



o Indicate that the dementia risk score is based upon a single point in time and the effects of treatment on the risk score have not been determined.



o This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be… Continue

Added by psychiatryRounds Psychiatry News on July 17, 2006 at 1:30am — No Comments

ICA: Poor Glycemic Control Increases Diabetics' Risk of Dementia

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that this study associated poor glycemic control with the eventual development of dementia. Point out however that the study cannot prove causality.



o Explain that aside from medication lifestyle changes, especially exercise, can help control blood sugar levels.



o This study was published as an abstract and presented orally at a conference. These data and conclusions should be… Continue

Added by psychiatryRounds Psychiatry News on July 17, 2006 at 1:30am — No Comments

ICAD: Risk Factors Total a Score to Predict Dementia Risk

(PSYCHIATRIC TIMES) - MADRID, July 17 -- There's a simple way, to calculate a middle-age patient's eventual dementia risk, on a scale of one to 15, according to Swedish investigators.



The risk score highlights the role of vascular factors in the development of dementia 20 years hence, said Tiia Ngandu, Ph.D., of the Karolinska Institute in Stockholm.



"It may help to identify individuals who can benefit from lifestyle changes and drug therapies," she said in a poster… Continue

Added by psychiatryRounds Psychiatry News on July 17, 2006 at 1:30am — No Comments

ICA: Poor Glycemic Control Increases Diabetics' Risk of Dementia

(PSYCHIATRIC TIMES) - MADRID, July 17 -- Diabetic patients with glycosylated hemoglobin (HbA1c) levels that are well out of control are driving down the road towards dementia, researchers said here Sunday.



Type 2 diabetes patients with HbA1c levels in excess of 15 have a 78% greater risk of developing dementia or Alzheimer's disease or cognitive decline in the next decade, said Rachel Whitmer, Ph.D., an investigator at Kaiser Permanente Northern California in Oakland.



For… Continue

Added by psychiatryRounds Psychiatry News on July 17, 2006 at 1:30am — No Comments

fMRI hints at the source of bipolar disorder

(PSYCHIATRIC TIMES) - Functional MRI data suggest that improper development of specific brain circuitries could beget bipolar disorder, according to National Institute of Mental Health researchers. Their findings underscore shifting beliefs regarding the origins of chronic psychiatric diseases.



Previous studies have shown that the amygdala — a brain's fear hub — is smaller in bipolar children than in healthy children of the same age. Data have shown also that bipolar children have… Continue

Added by psychiatryRounds Psychiatry News on July 14, 2006 at 4:30am — No Comments

Metabolic Syndrome Risk Doubles With Schizophrenia Drug

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that the antipsychotic medication clozapine is associated with increased risk for metabolic syndrome in patients with schizophrenia.



o Monitor patients who are taking Clozaril (clozapine) for body mass index, lipid levels, fasting blood glucose levels, and blood pressure.



ROCHESTER, N.Y., July 11 -- Patients taking the antipsychotic Clozaril (clozapine) for schizophrenia need to… Continue

Added by psychiatryRounds Psychiatry News on July 11, 2006 at 11:00pm — No Comments

Parkinson's Disease May Cause Apathy

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that in this small non-randomized study, researchers found that apathy may be a core feature of Parkinson's disease, and not necessarily a sign of depression.



GAINSEVILLE, Fla., July 10 -- Apathy independent of depression may be a feature of Parkinson's disease for some patients, researchers here have found.



In a study comparing 80 patients with Parkinson's with 20 others with… Continue

Added by psychiatryRounds Psychiatry News on July 10, 2006 at 1:30am — No Comments

No Autism-Vaccine Link, Researchers Re-Confirm

(PSYCHIATRIC TIMES) - MONTREAL, July 5 ? As the mercury-containing preservative thimerosal was removed from vaccines, and as fewer children received the mumps-measles-rubella vaccine, the rates of autism and related disorders rose among Canadian school children.



In a study of nearly 28,000 children born between 1987 and 1998, the prevalence of pervasive developmental disorders was greater in those children vaccinated after the mercury-containing compound thimerosal was completely… Continue

Added by psychiatryRounds Psychiatry News on July 5, 2006 at 3:30am — No Comments

Obesity Linked to Depression, or Vice Versa

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that obese persons have a 20% elevated risk of depression compared with those of normal weight, according to this study.



o Explain to patients who ask that this study did not establish a causal link between obesity and depression, but that there is evidence to suggest a possible causal relationship in either direction and it is also possible that common unmeasured factors play a… Continue

Added by psychiatryRounds Psychiatry News on July 5, 2006 at 1:30am — No Comments

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