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May 2007 News and Blog Posts (50)

Reducing Alzheimer's Protein Eases Deficits In Mice

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that amyloid-beta and tau are two proteins presumed to be involved in the pathogenesis of Alzheimer's disease.



o Explain that this study in mice suggests that lower levels of tau may prevent the symptoms of Alzheimer's even in the presence of large amounts of amyloid-beta.



o Caution that the research is preliminary and that more study is needed.



SAN FRANCISCO, May 4 --… Continue

Added by psychiatryRounds Psychiatry News on May 4, 2007 at 10:30pm — No Comments

Reducing Alzheimer's Protein Eases Deficits In Mice

SAN FRANCISCO, May 4 -- Reducing levels of one of the proteins involved in Alzheimer's disease appears to prevent some of memory loss and learning difficulties -- at least in experimental mice.



Researchers here crossed mice prone to develop an animal form of Alzheimer's with other mice lacking the gene for the protein tau, according to Lennart Mucke, M.D., of the University of California's Gladstone Institute of Neurological Disease.



For full article, please visit:…

Continue

Added by psychiatryRounds Psychiatry News on May 4, 2007 at 10:30pm — No Comments

3D MRI examines structural patterns of gray matter and bipolar disease

(PSYCHIATRIC TIMES) - Three-D MR imaging has led to new insights concerning the relationship between dysfunctional gray matter and the physiological effects of lithium therapy for bipolar disorders. The findings were reported in April in an online version of the journal Biological Psychiatry.



Three-D MR maps of brain structure confirmed earlier findings suggesting that lithium helps rebuild underused gray matter or repairs dysfunctional gray matter in specific regions of a bipolar… Continue

Added by psychiatryRounds Psychiatry News on May 4, 2007 at 4:00am — No Comments

AAN: New Analysis Reverses Thinking on Estrogen and Alzheimer's

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that the findings of the current analysis appear to contradict earlier indications that hormone replacement therapy may contribute to dementia. The findings need to be examined in much greater detail before therapeutic recommendations can be made.



o This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be preliminary… Continue

Added by psychiatryRounds Psychiatry News on May 3, 2007 at 10:30pm — No Comments

AAN: New Analysis Reverses Thinking on Estrogen and Alzheimer's

(PSYCHIATRIC TIMES) - BOSTON, May 3 -- Women who took estrogen before age 65 may not be at a higher risk of later dementia after all.



Contradicting earlier findings of an association between the use of estrogen and the later development of Alzheimer's disease, a deeper analysis of the evidence that led to that conclusion has found the opposite, reported Victor W, Henderson M.D., M.S. of Stanford University, and colleagues.



In fact, the new analysis suggests that women who… Continue

Added by psychiatryRounds Psychiatry News on May 3, 2007 at 10:30pm — No Comments

AAN: Migraine in Iraq Vets a Marker for Psychiatric Disorders

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Consider screening combat veterans with migraine for co-morbid psychiatric disorders such as depression, post-traumatic stress disorder, and/or anxiety.



o This study was published as an abstract and presented as a poster and in a briefing at a conference. These data and conclusions should be considered to be preliminary as they have not yet been reviewed and published in a peer-reviewed publication



BOSTON, May… Continue

Added by psychiatryRounds Psychiatry News on May 3, 2007 at 9:00pm — No Comments

The Assessment and Management of Depression in Children With Asthma

(PSYCHIATRIC TIMES) - Asthma is one of the most impairing diseases of childhood, affecting more than 6% of children.1 Each year, it is responsible for 14 million lost school days and $3 billion in treatment costs.1 The earliest definitions of asthma recognized the impact of psychological distress on the disorder. While most would agree that having a chronic illness increases the risk of depression, there is emerging evidence that depression may have an impact on the onset and course of asthma.… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 10:30pm — No Comments

AAN: Second-hand Smoke Can Add to Dementia Risk

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that in addition to the known contributions of second-hand or passive smoke to cancer and heart disease risk, this study suggests but does not demonstrate significantly that long-term exposure to someone else's smoke may increase the risk for dementia.



o This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 10:30pm — No Comments

News From the 59th Annual Meeting of the American Academy of Neurology, Boston, April 28 - May 5, 2007

(PSYCHIATRIC TIMES) - Personality Traits Early Clue to Distinguishing LBD From AD. Lewy body dementia (LBD) is often difficult to distinguish from Alzheimer disease (AD) but subtleties in symptoms provide clues to the differential diagnosis. With the aim of identifying clinical markers that would aid in the early differential diagnosis of LBD and AD, a team led by James E. Galvin, MD, MPH, assistant professor of neurology, anatomy, and neurobiology at Washington University School of Medicine in… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 10:30pm — No Comments

Physical Aggression in Dementia Patients

(PSYCHIATRIC TIMES) - In patients with dementia who are physically aggressive and dangerous to themselves or others, the use of intramuscular haloperidol or lorazepam may be appropriate. Because haloperidol causes less drowsiness and cognitive impairment than lorazepam, it is preferred in patients with dementia and delirium. The usual dose of haloperidol for elderly patients with dementia is 0.5 to 1 mg; this dose can be repeated every 25 to 30 minutes until the patient is no longer dangerous… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 10:30pm — No Comments

Dementia drugs give impetus to early and accurate diagnosis

(PSYCHIATRIC TIMES) - Dementia affects between 1% and 6% of people over the age of 65 and 10% to 20% of those over 80. As more and more individuals survive into old age, the absolute number of dementia sufferers is likely to soar.



The pharmaceutical industry has been quick to spot this expanding market, and treatments promising to slow the effects of dementia are becoming available. But given the symptomatic similarity of many disorders affecting brain function, it is not easy to… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 10:30pm — No Comments

Rise in dementia calls for early, accurate diagnosis

(PSYCHIATRIC TIMES) - Radiologists will play an increasingly important role in selecting the right patients for dementia treatment as more individuals survive into old age, according to neuroradiologists who spoke at the 2007 ECR.

For full article, please visit:
http://www.psychiatrictimes.com/alzheimer-dementia/article/113619/1184117

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 10:30pm — No Comments

News From the 59th Annual Meeting of the American Academy of Neurology, Boston, April 28 - May 5, 2007

(PSYCHIATRIC TIMES) - Personality Traits Early Clue to Distinguishing LBD From AD. Lewy body dementia (LBD) is often difficult to distinguish from Alzheimer disease (AD) but subtleties in symptoms provide clues to the differential diagnosis. With the aim of identifying clinical markers that would aid in the early differential diagnosis of LBD and AD, a team led by James E. Galvin, MD, MPH, assistant professor of neurology, anatomy, and neurobiology at Washington University School of Medicine in… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 8:30pm — No Comments

Anxiety Disorders: Aortic Aneurysm in the Differential?

(PSYCHIATRIC TIMES) - Anxiety disorders, including panic attacks, may have multiple cardiovascular causes, such as congestive heart failure, arrhythmias, angina, and mitral valve prolapse.1 A literature search of several databases (PsycINFO, PubMed, Medline, Biomedical Reference Collection, and Psychology & Behavioral Science Collection) revealed only 1 report of panic attack symptoms possibly related to an enlarging thoracic aortic aneurysm (TAA).2 However, possible connections have been… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 5:30am — No Comments

Suicide Attempts and Completions in Patients With Bipolar Disorder

(PSYCHIATRIC TIMES) - According to the CDC, in 2004, suicide was the 11th leading cause of death across all age groups and the 10th leading cause of death for persons aged 14 to 64 years; 32,439 people in the United States took their own lives.1 Women attempt suicide about 3 times more often than men, although men are 4 times as likely to complete suicide.2 Anderson and Smith3 reported that suicide was the eighth leading cause of death among men in 2001. Of the 24,672 completed suicides among… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 4:00am — No Comments

Quality of Life in Patients With Bipolar Disorder: Defining and Measuring Goals

(PSYCHIATRIC TIMES) - Bipolar disorder (BD) is a complex and heterogeneous condition characterized by a variety of symptoms and marked variability in disease course. A patient with BD can experience episodes of depression, hypomania, mania, or psychosis and, indeed, can experience a mixture of emotional states or cycle rapidly between them. In fact, recent research has highlighted the prevalence of marked subsyndromal features between episodes,1 but despite currently available treatments, BD… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 4:00am — No Comments

FACTITIOUS DISORDER

(PSYCHIATRIC TIMES) - Fliege H, Grimm A, Eckhardt-Henn A, et al. Frequency of ICD-10 factitious disorder: survey of senior hospital consultants and physicians in private practice. Psychosomatics. 2007;48:60-64.



Based on physicians' observations and experience, researchers in Germany estimated that 1.3% of patients have factitious disorder. This estimate was based on data from a physician questionnaire rather than the usual method of collecting data from case studies. The medical… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 4:00am — No Comments

Bipolar Diagnosis: Navigating Between Scylla and Charybdis

(PSYCHIATRIC TIMES) - When a new patient with depression enters your practice, you face a diagnostic dilemma. If you miss bipolar disorder (BD), and prescribe an antidepressant, you can do harm. But if you call a unipolar depression "bipolar," you may also do harm, because lithium, anticonvulsants, and atypical antipsychotics carry significant risk as both short- and long-term treatments. In addition, the label of "BD" currently carries much more stigma than the term… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 4:00am — No Comments

Suicide Attempts and Completions in Patients With Bipolar Disorder

(PSYCHIATRIC TIMES) - According to the CDC, in 2004, suicide was the 11th leading cause of death across all age groups and the 10th leading cause of death for persons aged 14 to 64 years; 32,439 people in the United States took their own lives.1 Women attempt suicide about 3 times more often than men, although men are 4 times as likely to complete suicide.2 Anderson and Smith3 reported that suicide was the eighth leading cause of death among men in 2001. Of the 24,672 completed suicides among… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 4:00am — No Comments

The Case for Polypharmacy in the Treatment of Bipolar Disorder

(PSYCHIATRIC TIMES) - In addition to being complex and pleomorphic in its own right, bipolar disorder is often accompanied by a host of other medical and psychiatric comorbidities. Recent evidence suggests that the illness is not as benign as originally considered and in some academic and outpatient settings, patients remain symptomatic almost half of their lives despite naturalistic treatment in the community. Bipolar disorder has considerable morbidity and mortality, both from suicide and… Continue

Added by psychiatryRounds Psychiatry News on May 1, 2007 at 4:00am — No Comments

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