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May 2007 News and Blog Posts (50)

Personality Changes May Help Distinguish Between Types of Dementia

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients that significant personality changes among older adults may be an early sign of dementia.



o Explain, too, that increased passivity may be a sign of dementia with Lewy bodies, not Alzheimer's dementia, which is more likely to be presaged by irritability.



ST. LOUIS, May 31 -- The appearance of passive personality traits in an older adult with signs of dementia may signal the presence of Lewy… Continue

Added by psychiatryRounds Psychiatry News on May 31, 2007 at 10:00pm — No Comments

Personality Changes May Help Distinguish Between Types of Dementia

(PSYCHIATRIC TIMES) - ST. LOUIS, May 31 -- The appearance of passive personality traits in an older adult with signs of dementia may signal the presence of Lewy bodies rather than Alzheimer's disease, said investigators here.



Among 290 older adults in a longitudinal study, specific personality traits involving social withdrawal and purposeless hyperactivity helped distinguish between the two types of dementia, wrote James E. Galvin, M.D., M.P.H., of the Alzheimer Disease Research… Continue

Added by psychiatryRounds Psychiatry News on May 31, 2007 at 10:00pm — No Comments

Inflammatory Cytokines Linked to Alzheimer's Risk

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that there is conflicting evidence to suggest that inflammation may play a role in the development of Alzheimer's disease.



BOSTON, May 30 -- There's more evidence to support the inflammatory hypothesis of Alzheimer's disease, a finding that emerged from the Framingham Heart study cohort.



Higher levels of inflammatory cytokines produced by peripheral blood cell suggested they are a… Continue

Added by psychiatryRounds Psychiatry News on May 30, 2007 at 10:30pm — No Comments

Inflammatory Cytokines Linked to Alzheimer's Risk

(PSYCHIATRIC TIMES) - BOSTON, May 30 -- There's more evidence to support the inflammatory hypothesis of Alzheimer's disease, a finding that emerged from the Framingham Heart study cohort.



Higher levels of inflammatory cytokines produced by peripheral blood cell suggested they are a risk marker for dementia, reported Zaldy S. Tan, M.D., M.P.H., of Harvard, and colleagues, in the May 29 issue of Neurology



In a study of 691 cognitively intact seniors who were part of the… Continue

Added by psychiatryRounds Psychiatry News on May 30, 2007 at 10:00pm — No Comments

Novel PET agent breaks through in Alzheimer’s diagnosis

(PSYCHIATRIC TIMES) - A new PET agent could help neuroimagers accurately tell the difference between the brains of Alzheimer's disease patients and those of healthy aging individuals, according to a study published in the Journal of Nuclear Medicine.



The accumulation of amyloid plaque represents the most typical neuropathological hallmark of Alzheimer's disease. PET, with the aid of radiopharmaceutical agents that bind to amyloid plaque, is the leading imaging technique for the… Continue

Added by psychiatryRounds Psychiatry News on May 25, 2007 at 10:30pm — No Comments

APA: Most Bipolar Patients Start on Off-Label Antidepressants

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that drug therapy for depression associated with bipolar disorder may include mood stabilizers and/or antimanic agents.



o This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be preliminary as they have not yet been reviewed and published in a peer-reviewed publication.



SAN DIEGO, May 24 -- Antidepressants… Continue

Added by psychiatryRounds Psychiatry News on May 24, 2007 at 10:30pm — No Comments

APA: Psychiatrists Want More Effective Antipsychotics

(PSYCHIATRIC TIMES) - MedPage Today Action Points



SAN DIEGO, May 24 -- Pharmacotherapy for schizophrenia may be better than it's ever been, but it's not nearly good enough.



In a nationwide survey of psychiatrists, 95% said that there is a need for new, highly effective drug options, said Peter Buckley, M.D., of the Medical College of Georgia.



About the same percentage of respondents said that their patients would directly benefit from such therapies, said Dr.… Continue

Added by psychiatryRounds Psychiatry News on May 24, 2007 at 10:30pm — No Comments

APA: Co-Morbid ADHD in Bipolar Adults May Respond To Non-Stimulants

(PSYCHIATRIC TIMES) - SAN DIEGO, May 24 -- When attention deficit hyperactivity disorder meets bipolar disorder in an adult, the diagnosis is hard and the course is poorly understood but the co-morbidity appears to exacerbate matters, researchers said here.



A systematic review of rates of bipolar disorder and ADHD in adults revealed that co-morbidity ranges anywhere from about 5% to 47%, reported Aliza P. Wingo, M.D., and S. Nassir Ghaemi, M.D., M.P.H., of Emory University in… Continue

Added by psychiatryRounds Psychiatry News on May 24, 2007 at 4:00am — No Comments

APA: Most Bipolar Patients Start on Off-Label Antidepressants

(PSYCHIATRIC TIMES) - SAN DIEGO, May 24 -- Antidepressants are widely used to treat the depression in bipolar disorder, despite their lack of approval for the indication and limited evidence of efficacy and safety, investigators reported here.



A review of nationwide prescribing patterns of psychotropic drugs for patients with diagnosed bipolar disorder revealed that more than half received antidepressants as initial monotherapy, with anticonvulsant drugs coming in a distant second,… Continue

Added by psychiatryRounds Psychiatry News on May 24, 2007 at 4:00am — No Comments

APA: Co-Morbid ADHD in Bipolar Adults May Respond To Non-Stimulants

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that a diagnosis of co-morbid bipolar disorder and attention deficit hyperactivity disorder in adults is challenging, because many of the symptoms overlap.



o This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be preliminary as they have not yet been reviewed and published in a peer-reviewed publication.



SAN… Continue

Added by psychiatryRounds Psychiatry News on May 24, 2007 at 2:30am — No Comments

APA: Successor to Effexor Effective Against Anxiety in Depression

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that desvenlafaxine, a serotonin-norepinephrine reuptake inhibitor, is awaiting final approval from the FDA, and is not currently on the market.



o This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be preliminary until they have been published in a peer-reviewed publication.



SAN DIEGO, May 23 -- The novel… Continue

Added by psychiatryRounds Psychiatry News on May 23, 2007 at 5:30am — No Comments

APA: Successor to Effexor Effective Against Anxiety in Depression

(PSYCHIATRIC TIMES) - SAN DIEGO, May 23 -- The novel serotonin-norepinephrine reuptake inhibitor desvenlafaxine succinate (Pristiq) was significantly superior to placebo in the treatment of anxiety symptoms in depression, results of a pooled analysis showed.



In seven randomized, placebo controlled studies, patients on desvenlafaxine had significantly greater improvement from baseline to week eight, compared with placebo, on anxiety items of the 17-item Hamilton Depression Rating… Continue

Added by psychiatryRounds Psychiatry News on May 23, 2007 at 5:30am — No Comments

APA: Research Sheds Light on Actions of Atypical Antipsychotics

(PSYCHIATRIC TIMES) - MedPage Today Action Points



SAN DIEGO, May 22 -- The key to the efficacy of atypical or second-generation antipsychotic agents in treatment of schizophrenia is their affinity for binding to and occupying the dopamine D2 receptor.



So said Gordon Frankle, M.D., of the University of Pittsburgh. Dr. Frankle discussed the neurobiology of schizophrenia at a satellite symposium presented in conjunction with the American Psychiatric Association meeting… Continue

Added by psychiatryRounds Psychiatry News on May 22, 2007 at 10:30pm — No Comments

ATS: End-of-Life Discussions in ICU Reduce Family Members' Grief

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that while the family conferences showed benefit in France, cultural backgrounds may vary response in other countries.



SAN FRANCISCO, May 22 -- Better communication with the family of dying ICU patients may reduce stress, anxiety, and depression, French researchers found.



Relatives were about 25% less likely to suffer those outcomes when they took part in a family conference with… Continue

Added by psychiatryRounds Psychiatry News on May 22, 2007 at 5:30am — No Comments

Functional MRI correlates brain activity with emotional response in autistic children

(PSYCHIATRIC TIMES) - Functional MR scans have confirmed that levels of brain function are low or nonexistent in autistic patients viewing stimuli designed to provoke emotional activity, according to studies presented at the International Meeting for Autism Research held in early May in Seattle.



Research led by Dr. Susan Bookheimer, a professor of psychiatry and behavioral sciences at the University of California, Los Angeles's Semel Institute of Neuroscience and Human Behavior, and… Continue

Added by psychiatryRounds Psychiatry News on May 21, 2007 at 3:30am — No Comments

Thimerosal-Autism Link Discounted in RhIg Study

(PSYCHIATRIC TIMES) - COLUMBIA, Mo., May 16 -- Prenatal exposure to thimerosal in Rh immunoglobulin (RhIg) does not increase a child's risk for an autism spectrum disorder, said investigators here.



Compared with women in the general population, mothers of children with autism were no more likely to be Rh negative, to have received RhIg preserved with thimerosal during pregnancy, or to have had pregnancies complicated by Rh incompatibility, reported Judith Miles, M.D., Ph.D., and… Continue

Added by psychiatryRounds Psychiatry News on May 16, 2007 at 3:30am — No Comments

Bipolar Disorder Prevalence Hidden by Diagnostic Thresholds

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that bipolar disorder that does not quite meet diagnostic criteria appears to be common.



o Caution patients that subthreshold bipolar disorder is not well defined and does not have clear treatment guidelines.



BETHESDA, Md., May 8 -- There may be twice as many patients with bipolar spectrum disorders as generally suspected, according to a national survey.



The survey… Continue

Added by psychiatryRounds Psychiatry News on May 8, 2007 at 4:00am — No Comments

Bipolar Disorder Prevalence Hidden by Diagnostic Thresholds

(PSYCHIATRIC TIMES) - BETHESDA, Md., May 8 -- There may be twice as many patients with bipolar spectrum disorders as generally suspected, according to a national survey.



The survey found that 4.4% of Americans have had a form of bipolar disorder at some point in their lifetime, whereas the prevalence of bipolar I and II combined over a lifetime is typically cited at about 1.9%.



The difference was attributed to the 2.4% prevalence of "subthreshold" bipolar disorder,… Continue

Added by psychiatryRounds Psychiatry News on May 8, 2007 at 4:00am — No Comments

Monthly Maintenance Psychotherapy Helps Ward Off Recurrent Depression

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that for many women with recurrent depression who achieved remission via depression-specific psychotherapy but without drug therapy, even a once monthly booster session may hold off recurrence.



PITTSBURGH, May 7 -- For women with depression who achieved remission with interpersonal psychotherapy, a monthly therapy booster prevented recurrence for 74% of patients over two years, researchers… Continue

Added by psychiatryRounds Psychiatry News on May 7, 2007 at 9:30pm — No Comments

Monthly Maintenance Psychotherapy Helps Ward Off Recurrent Depression

(PSYCHIATRIC TIMES) - PITTSBURGH, May 7 -- For women with depression who achieved remission with interpersonal psychotherapy, a monthly therapy booster prevented recurrence for 74% of patients over two years, researchers reported.



On the other hand, for patients who required drug therapy coupled with psychotherapy to achieve remission, psychotherapy alone for the few patients who remained in the study was significantly less effective, Ellen Frank, Ph.D., of the University of… Continue

Added by psychiatryRounds Psychiatry News on May 7, 2007 at 9:30pm — No Comments

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