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April 2007 News and Blog Posts (24)

U.S. PSYCH: Depression Remission Rates Remain Low, But There's Hope

(PSYCHIATRIC TIMES) - MedPage Today Action Points



SAN FRANCISCO, April 25 -- Remission rates remain low for major depression even with multiple antidepressant drug classes available, but the recently approved selegiline patch (Emsam) aims to bring the rates up.



"The mission for the condition is remission," said James W. Jefferson, M.D., of the University of Wisconsin in Madison, but "we are still stuck with this low remission rate."



Just getting a response with… Continue

Added by psychiatryRounds Psychiatry News on April 26, 2007 at 10:30pm — No Comments

U.S. PSYCH: Insomnia Treatment Boosts Antidepressant Efficacy

(PSYCHIATRIC TIMES) - SAN FRANCISCO, April 25 -- A significant number of patients with major depression also suffer from chronic insomnia that hampers recovery, a sleep expert said here.



"Treating the insomnia pharmacologically or behaviorally can improve outcomes in depression," said Christopher L. Drake, Ph.D., of the Henry Ford Hospital Sleep Disorders and Research Center in Detroit.



The prevalence of insomnia comorbid with psychiatric disorders is 40.4%, with major… Continue

Added by psychiatryRounds Psychiatry News on April 26, 2007 at 6:00am — No Comments

USPSYCH: New Definitions on Tap for Mixed Manias

(PSYCHIATRIC TIMES) - MedPage Today Action Points



SAN FRANCISCO, April 25 -- Dysphoric mania and other mixed mania states of bipolar disorder will become easier to diagnose with better definitions, a researcher said here.



"We don't have a very clean way to capture all the mixed states," said Trisha Suppes, M.D., Ph.D., of the University of Texas Southwestern Medical Center at Dallas. She presented working definitions and an algorithm for treatment here at the U.S.… Continue

Added by psychiatryRounds Psychiatry News on April 26, 2007 at 4:00am — No Comments

USPSYCH: New Definitions on Tap for Mixed Manias

(PSYCHIATRIC TIMES) - SAN FRANCISCO, April 25 -- Dysphoric mania and other mixed mania states of bipolar disorder will become easier to diagnose with better definitions, a researcher said here.



"We don't have a very clean way to capture all the mixed states," said Trisha Suppes, M.D., Ph.D., of the University of Texas Southwestern Medical Center at Dallas. She presented working definitions and an algorithm for treatment here at the U.S. Psychiatric and Mental Health Congress regional… Continue

Added by psychiatryRounds Psychiatry News on April 26, 2007 at 4:00am — No Comments

U.S. PSYCH: Atypical Antipsychotic Medication Cuts Behavioral Symptoms in Autism

(PSYCHIATRIC TIMES) - MedPage Today Action Points



SAN FRANCISCO, April 25 -- While the behavioral symptoms of autism have been treated with a wide spectrum of medications, atypical antipsychotics may be the most effective drug class.



So said Lawrence D. Scahill, Ph.D., of Yale University, in a presentation here at the U.S. Psychiatric and Mental Health Congress regional extension.



Serious behavioral problems accompany autism in 20% to 30% of cases and include… Continue

Added by psychiatryRounds Psychiatry News on April 26, 2007 at 3:30am — No Comments

Forget NSAIDs for Alzheimer's Prevention

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that there is currently no strong evidence to support the use of NSAIDs for primary prevention of Alzheimer's disease or related forms of dementia. In fact, evidence from the ADAPT study hints at a possible negative effect of naproxen (Aleve) and celecoxib (Celebrex) on dementia risk.



BALTIMORE, April 25 -- Neither naproxen (Aleve) nor celecoxib (Celebrex) reduced the risk of developing… Continue

Added by psychiatryRounds Psychiatry News on April 25, 2007 at 10:30pm — No Comments

Forget NSAIDs for Alzheimer's Prevention

(PSYCHIATRIC TIMES) - BALTIMORE, April 25 -- Neither naproxen (Aleve) nor celecoxib (Celebrex) reduced the risk of developing Alzheimer's disease, at least in the short term, investigators from the suspended ADAPT trial reported.



According to results of the randomized study funded by the National Institute on Aging, there was even a suggestion that both naproxen and celecoxib were associated with a slightly increased risk of dementia, reported Constantine Lyketsos, M.D., M.H.S., of… Continue

Added by psychiatryRounds Psychiatry News on April 25, 2007 at 10:30pm — No Comments

USPSYCH: Concurrent Treatment Works for Comorbid ADHD and Substance Abuse

(PSYCHIATRIC TIMES) - SAN FRANCISCO, April 25 -- Given the high prevalence of substance abuse in patients with attention deficit hyperactivity disorder (ADHD), psychiatrists need to consider comorbidity in assessment of both conditions. Despite concerns over the role that stimulant drug treatment has in increasing the risk for substance abuse disorders among individuals with ADHD, treating early seems to serve a protective role, said Scott H. Kollins, Ph.D., of Duke University.



He… Continue

Added by psychiatryRounds Psychiatry News on April 25, 2007 at 1:30am — No Comments

USPSYCH: Concurrent Treatment Works for ComorbidADHD and Substance Abuse

(PSYCHIATRIC TIMES) - SAN FRANCISCO, April 25 -- Given the high prevalence of substance abuse in patients with attention deficit hyperactivity disorder (ADHD), psychiatrists need to consider comorbidity in assessment of both conditions. Despite concerns over the role that stimulant drug treatment has in increasing the risk for substance abuse disorders among individuals with ADHD, treating early seems to serve a protective role, said Scott H. Kollins, Ph.D., of Duke University.



He… Continue

Added by psychiatryRounds Psychiatry News on April 25, 2007 at 1:30am — No Comments

Magnetoencephalography identifies Alzheimer’s disease

(PSYCHIATRIC TIMES) - Conventional diagnostics such as functional MR cannot capture the fleeting brain activity indicative of brain diseases such as Alzheimer's disease, according to University of Minnesota researchers. The communication patterns form and disappear in microseconds, too short a time for chemically based imaging to grasp. They consider magnetoencephalography a better tool.



MEG has been kicking around the medical imaging community for years as a mapping tool, but its… Continue

Added by psychiatryRounds Psychiatry News on April 23, 2007 at 10:00pm — No Comments

Meta-Analysis Finds Antidepressants' Benefits Counter Risks for Kids

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that this large study found that pediatric antidepressants were most effective for certain anxiety disorders followed by major depression.



o Inform interested patients, that the 1% increased risk of suicidal thoughts or attempts in these young people was not statistically significant and that there were no actual suicides.



COLUMBUS, OH, April 17 -- The benefits of antidepressants for… Continue

Added by psychiatryRounds Psychiatry News on April 17, 2007 at 5:30am — No Comments

Factitious Disorder: Detection, Diagnosis, and Forensic Implications

(PSYCHIATRIC TIMES) - fac ti tious adj.1. Produced artificially rather than by natural process; contrived. 2. Lacking authenticity or genuineness; sham. [Latin facticius, made by art; from facere, to make, do]

More Like This



Factitious Disorder



Pathological Lying: Symptom or Disease?



The Joker and the Thief: Persistent Malingering as a Specific Type of Therapeutic Impasse



Malingering: Key Points in Assessment



More >… Continue

Added by psychiatryRounds Psychiatry News on April 15, 2007 at 4:00am — No Comments

Diabetes Linked to Mild Cognitive Impairment

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that the prevalence of diabetes is higher among African Americans and Hispanics, compared with whites, which could account for the higher rate of mild cognitive impairment.



o Explain that mild cognitive impairment is a risk factor for later Alzheimer's disease, but could be caused by other correctable factors such as cerebrovascular disease.



NEW YORK, April 9 -- Diabetes increases… Continue

Added by psychiatryRounds Psychiatry News on April 9, 2007 at 10:30pm — No Comments

Autopsy confirms that compound binds to amyloid plaque in human brain

(PSYCHIATRIC TIMES) - The autopsy of a man evaluated for dementia with Pittsburgh compound B has revealed for the first time that the imaging agent binds to the protein in amyloid plaques that characterize Alzheimer's disease in the human brain. The findings come from a study by researchers at Massachusetts General Hospital that appeared in the March issue of Archives of Neurology.



The autopsy confirmed the diagnosis of dementia with Lewy bodies and produced several findings… Continue

Added by psychiatryRounds Psychiatry News on April 4, 2007 at 10:30pm — No Comments

Binge Eating Disorder: Surprisingly Common, Seriously Under-treated

(PSYCHIATRIC TIMES) - Though binge eating is not an officially recognized psychiatric disorder, it is more common than anorexia nervosa and bulimia; carries serious health risks; can be chronic; transcends racial, gender and socioeconomic boundaries; and frequently occurs along with other mental disorders.



Given these findings -- taken from the first nationally representative survey of eating disorders in the U.S. -- experts say physicians should routinely screen for binge eating… Continue

Added by psychiatryRounds Psychiatry News on April 3, 2007 at 4:00am — No Comments

Talk, Talk, Talk Speeds Bipolar Recovery

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that this study shows that intensive psychotherapy - in any of three forms - helps speed the recovery from depression for patients with bipolar disorder.



BOULDER, Colo., April 2 -- Intensive psychotherapy, coupled with medication, speeds recovery from depression for patients with bipolar disorder, according to researchers here.



In a randomized trial, depressed bipolar patients… Continue

Added by psychiatryRounds Psychiatry News on April 2, 2007 at 9:30pm — No Comments

Talk, Talk, Talk Speeds Bipolar Recovery

(PSYCHIATRIC TIMES) - BOULDER, Colo., April 2 -- Intensive psychotherapy, coupled with medication, speeds recovery from depression for patients with bipolar disorder, according to researchers here.



In a randomized trial, depressed bipolar patients getting any of three forms of intensive psychotherapy recovered more rapidly than those given a brief, three-session intervention, found David Miklowitz, Ph.D., of the University of Colorado. and colleagues, reported in the April issue of… Continue

Added by psychiatryRounds Psychiatry News on April 2, 2007 at 4:00am — No Comments

Brain Stimulation Therapies Offer New Hope for Treatment-Resistant Depression

(PSYCHIATRIC TIMES) - Treatment-resistant depression (TRD) is generally defined as depression that has not responded to at least 2 adequate trials of antidepressant drugs from different pharmacological classes.1 Other more stringent definitions might also require the failure of 1 or 2 augmentation strategies (eg, lithium [Eskalith, Lithobid] or thyroid augmentation of an antidepressant; or combination therapy using 2 different antidepressants).2 Depression might not be considered truly… Continue

Added by psychiatryRounds Psychiatry News on April 1, 2007 at 10:30pm — No Comments

Understanding Medication Discontinuation in Depression

(PSYCHIATRIC TIMES) - Compared with schizophrenia, adherence behavior has been relatively overlooked in depression and other mood disorders.1-3 Major depression is increasingly thought of as a chronic illness.4 In most chronic illnesses, ideal concordance is the exception, not the rule. Barber and colleagues5 found that only 16% of patients taking medication for stroke, coronary heart disease, asthma, diabetes mellitus, and rheumatoid arthritis were adherent, problem-free, and in receipt of… Continue

Added by psychiatryRounds Psychiatry News on April 1, 2007 at 10:30pm — No Comments

Benefits of Early Pharmacological Treatment in Alzheimer Disease

(PSYCHIATRIC TIMES) - As the aging of the world population continues, the number of people affected by dementia is likely to steadily increase. It is estimated that there are 4.5 million affected people in United States alone and that this number will triple in the first half of this century. Alzheimer disease (AD), the most common form of dementia, remains a major public health challenge internationally. This disease not only exacts a heavy toll on patients but also causes anguish to millions… Continue

Added by psychiatryRounds Psychiatry News on April 1, 2007 at 10:30pm — No Comments

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