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March 2009 News and Blog Posts (9)

Comorbidity in Bipolar Disorder

(PSYCHIATRIC TIMES) - The central tenet of clinical comorbidity, the occurrence of 2 syndromes in the same patient, presupposes that they are distinct categorical entities. By this definition, 2 or more coexisting syndromes do not negate one another, nor paradoxically does this coexistence negate the potential for one to influence the course, outcome, and treatment response of the other. Isolating a syndrome by characterizing it through a unique pathogenic process allows for diagnostic fidelity… Continue

Added by psychiatryRounds Psychiatry News on March 23, 2009 at 5:00am — No Comments

Comorbidity in Bipolar Disorder

(PSYCHIATRIC TIMES) - The central tenet of clinical comorbidity, the occurrence of 2 syndromes in the same patient, presupposes that they are distinct categorical entities. By this definition, 2 or more coexisting syndromes do not negate one another, nor paradoxically does this coexistence negate the potential for one to influence the course, outcome, and treatment response of the other. Isolating a syndrome by characterizing it through a unique pathogenic process allows for diagnostic fidelity… Continue

Added by psychiatryRounds Psychiatry News on March 23, 2009 at 3:00am — No Comments

Cognitive Impairments Found With Attention-Deficit/Hyperactivity Disorder

(PSYCHIATRIC TIMES) - Over the past century, the syndrome currently referred to as attention-deficit/hyperactivity disorder (ADHD) has been conceptualized in relation to varying cognitive problems including attention, reward response, executive functioning, and other cognitive processes.1 More recently, it has become clear that whereas ADHD is associated at the group level with a range of cognitive impairments, no single cognitive dysfunction characterizes all children with ADHD.2,3 In other… Continue

Added by psychiatryRounds Psychiatry News on March 18, 2009 at 3:00am — No Comments

Genetic Polymorphism and Major Depression: New Theories

(PSYCHIATRIC TIMES) - Genetic studies are slowly leading to a better understanding of certain diseases as well as progress toward individualized drug therapy. Developments in DNA sequencing make it relatively simple to look for allelic (ie, alternative) versions of a gene by examining samples of a specific gene taken from different members of a population (or from a heterozygous individual). Genetic variants that appear in at least 1% of a population are called polymorphisms. With the cutoff at… Continue

Added by psychiatryRounds Psychiatry News on March 13, 2009 at 9:30pm — No Comments

Cognitive Difficulties Associated With Depression

(PSYCHIATRIC TIMES) - Subjective complaints of impaired concentration, memory, and attention are common in people with major depressive disorder (MDD), and research shows that a variety of structural brain abnormalities are associated with MDD.1 These findings have intensified the interest in quantitative assessment of cognitive and neuropsychological performance in patients with mood disorders. Many studies that used standardized cognitive tests have found that mild cognitive abnormalities are… Continue

Added by psychiatryRounds Psychiatry News on March 11, 2009 at 9:30pm — No Comments

Fishing for Genetic Links in Autism

(PSYCHIATRIC TIMES) - In my January column (“Fishing Expeditions and Autism: A Big Catch for Genetic Research?” Psychiatric Times, January 2009, page 12), I described the great difficulties researchers face characterizing the genetic basis of the disease. Complexities range from trying to establish a stable diagnostic profile to making sense of the few isolated mutations that show clear associations (either with disease or syndrome variants).



Using the metaphor of a fishing net, I… Continue

Added by psychiatryRounds Psychiatry News on March 11, 2009 at 3:30am — No Comments

Mortality With Antipsychotic Use in Alzheimer Disease

(PSYCHIATRIC TIMES) - Mortality in elderly patients with dementia markedly and progressively increases with extended use of antipsychotics, according to the first long-term controlled study of risk in this population. Earlier evidence of this risk was from short-term trials not exceeding 14 weeks.



Clive Ballard, MD, King's College, London, and colleagues1 recently reported on the dementia antipsychotic withdrawal trial (DART-AD), a 12-month, placebo-controlled study of 165 patients… Continue

Added by psychiatryRounds Psychiatry News on March 4, 2009 at 8:30pm — No Comments

Volumetric MRI produces Alzheimer's early warning

(PSYCHIATRIC TIMES) - MRI measures of regional brain atrophy, taken at the University of California, San Diego, have established the basis for a new way to diagnose Alzheimer's disease.



Radiology professors Andres Dale, Ph.D., and Dr. Carl Hoh, neurologist Dr. James Brewer, and radiology resident Dr. David Karow saw that volumetric MRI potentially fulfilled the need for a less expensive and less invasive test for early diagnosis of the disease and for drug research and… Continue

Added by psychiatryRounds Psychiatry News on March 1, 2009 at 8:30pm — No Comments

Anxiety Disorders: Guidelines for Effective Primary Care, Part 1, Diagnosis

(PSYCHIATRIC TIMES) - Anxiety disorders are as prevalent and disabling as depression; they affect about 19.1 million adults in the United States at some point during their lifetimes.1-3 Because of the high suicide risk associated with depression, patients who have anxiety may attract less attention from their primary care providers. Thus, anxiety disorders often go undiagnosed and untreated.



At least 60% of patients with symptoms of anxiety disorders seek treatment in a primary care… Continue

Added by psychiatryRounds Psychiatry News on March 1, 2009 at 3:00am — No Comments

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