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February 2007 News and Blog Posts (27)

Women Soldiers Respond to PTSD Therapy for Precipitating Event

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that both cognitive therapy paradigms used in this study -- prolonged exposure and present-centered therapies -- were effective, but more women achieved complete remission with prolonged exposure therapy.



o Point out that the women in the study achieved benefit even through triggering events occurred more than 20 years before treatment.



WHITE RIVER JUNCTION, Vt., Feb. 28 -- For… Continue

Added by psychiatryRounds Psychiatry News on February 28, 2007 at 9:30pm — No Comments

ADHD Drug Designed to Limit Abuse Wins FDA Okay

(PSYCHIATRIC TIMES) - MedPage Today Action Points



ROCKVILLE, Md., Feb. 27 -- The FDA has approved lisdexamfetamine dimesylate (Vyvanse), formerly known as NRP104, for attention deficit hyperactivity disorder.



The amphetamine, to be marketed by Shire, is said to have limited abuse potential, but it was designated Schedule II by the DEA. Shire plc said in a statement that the drug has a lower potential for abuse than other amphetamines used to treat ADHD.



"The… Continue

Added by psychiatryRounds Psychiatry News on February 27, 2007 at 3:00am — No Comments

FDA Orders ADHD Drug Advisories for Patients

(PSYCHIATRIC TIMES) - MedPage Today Action Points



ROCKVILLE, Md., Feb. 22 -- The FDA has ordered all drugs approved for attention deficit hyperactivity disorder to carry guides to inform patients about the potential for cardiovascular risks and adverse psychiatric symptoms.



"Medicines approved for the treatment of ADHD have real benefits for many patients but they may have serious risks as well," said Steven Galson, M.D., director of the FDA's Center for Drug Evaluation… Continue

Added by psychiatryRounds Psychiatry News on February 22, 2007 at 3:00am — No Comments

Drug Reduces Alzheimer's-Like Tau Tangles in Mice

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that one of the characteristics of Alzheimer's disease is the formation of protein tangles in the brain, which are thought to impair the function of axons.



o Point out that this study with mice suggests that forcing a chaperone protein in the brain into a search-and-destroy mode may be a way to reduce the accumulation of the tangles.



o Explain this research is in a very early… Continue

Added by psychiatryRounds Psychiatry News on February 16, 2007 at 10:30pm — No Comments

Autism Disorder Reversed in Mice

(PSYCHIATRIC TIMES) - EDINBURGH, Scotland, Feb. 9 -- Rett syndrome -- a relatively rare autism spectrum disorder -- may be reversible, if experiments in mice are borne out in humans.



The syndrome, which affects about one in 10,000 girls, is caused by mosaic expression of mutations in the X-linked gene MECP2 and destroys speech, normal movement, and use of the hands, although there is no loss of neurons, according to Adrian Bird, Ph.D., of the University of Edinburgh.



For… Continue

Added by psychiatryRounds Psychiatry News on February 9, 2007 at 4:00am — No Comments

Autism Spectrum Disorders Far More Prevalent Than Thought

(PSYCHIATRIC TIMES) - ATLANTA, Feb. 8 -- Autism spectrum disorders are much more common than previously thought, and could affect as many as one in 150 school-age children, CDC researchers reported today.



"Autism is more common than we believed and is an urgent public health problem," said Catherine Rice, Ph.D., a behavioral scientist at the CDC's National Center on Birth Defects and Developmental Disabilities, in a briefing.



Data from a nationwide surveillance program… Continue

Added by psychiatryRounds Psychiatry News on February 8, 2007 at 3:30am — No Comments

Symptoms of Depression May Be Hazardous to Heart

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that this suggests that some symptoms of depression may be associated with the development of atherosclerosis.



o Explain to interested patients that the findings in this report need to be confirmed in other studies and other patient populations.



PITTSBURGH, Feb. 7 -- Common symptoms of depression such as fatigue, sleep disturbances, and anhedonia may trigger initima-media… Continue

Added by psychiatryRounds Psychiatry News on February 7, 2007 at 11:00pm — No Comments

Symptoms of Depression May Be Hazardous to Heart

(PSYCHIATRIC TIMES) - PITTSBURGH, Feb. 7 -- Common symptoms of depression such as fatigue, sleep disturbances, and anhedonia may trigger initima-media thickness changes associated with subclinical atherosclerosis, researchers here reported.



In a study of 324 healthy older adults, higher depressive symptoms at baseline were significantly associated with greater three-year change in intima-media thickness (?R2 =0.026, P=0.002), found Jesse C. Stewart, Ph.D. of the University of… Continue

Added by psychiatryRounds Psychiatry News on February 7, 2007 at 11:00pm — No Comments

Cell Culture Experiments Link Florane to Dementia

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that Alzheimer's disease is characterized by the death of neurons and the build-up of amyloid-? plaques in the brain.



o Note that this study suggests that a commonly used general anesthetic causes a vicious cycle of cell death and plaque accumulation.



o Caution that the finding arises from experiments in cultured cells and not in human beings, so that more research is needed to… Continue

Added by psychiatryRounds Psychiatry News on February 7, 2007 at 10:30pm — No Comments

Cell Culture Experiments Link Florane to Dementia

(PSYCHIATRIC TIMES) - BOSTON, Feb. 7 -- A commonly used general anesthetic creates a vicious cycle of cell death and deposits of Alzheimer's disease proteins -- at least in cell culture.



In laboratory experiments with cultured neuroglioma cells, Florane (isoflurane) was linked to increases in apoptosis as well as generation and aggregation of amyloid-?, whose deposits in the brain are characteristic of Alzheimer's, according to Zhongcong Xie, M.D., Ph.D., of the Massachusetts General… Continue

Added by psychiatryRounds Psychiatry News on February 7, 2007 at 10:30pm — No Comments

Lonely Souls Susceptible to Alzheimer's Disease

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that the link between loneliness and increased risk for dementia is unclear, but may be related to behavioral changes brought on by dementia, or by changes in brain function caused by reaction to social isolation.



CHICAGO, Feb. 5 -- Older men and women who are lonely are twice as likely to develop Alzheimer's-type dementia as their peers with good social networks, researchers have… Continue

Added by psychiatryRounds Psychiatry News on February 5, 2007 at 10:30pm — No Comments

Lonely Souls Susceptible to Alzheimer's Disease

(PSYCHIATRIC TIMES) - CHICAGO, Feb. 5 -- Older men and women who are lonely are twice as likely to develop Alzheimer's-type dementia as their peers with good social networks, researchers have found.



The elevated risk for dementia among the lonely was unrelated to medical causes for Alzheimer's disease or other forms of dementia, suggesting that the social isolation may lead to dementia by another route, wrote Robert S. Wilson, Ph.D., and colleagues at Rush University here and the… Continue

Added by psychiatryRounds Psychiatry News on February 5, 2007 at 10:30pm — No Comments

Ketamine and NMDA Receptor Antagonists for Depression

(PSYCHIATRIC TIMES) - In recent months, it's been the rare week that doesn't come with a report about the dangers of antidepressants. These drugs do have their drawbacks, but the dangers they pose are not their main problem. Their biggest shortcoming is that they don't work very well; fewer than half of the patients treated with them get complete relief, and that relief takes an unacceptably long time—2 to 3 weeks—to kick in.



This is why a recent report1 showing that a single… Continue

Added by psychiatryRounds Psychiatry News on February 1, 2007 at 11:00pm — No Comments

Depression and Diet in Elderly Community-Dwelling Mexican and European Americans

(PSYCHIATRIC TIMES) - Elderly persons with illnesses and inadequate nutrition can manifest age-associated cognitive, emotional, and behavioral disorders.1 If untreated, mental health issues may contribute to the public health burden of disability as the proportion of older persons in the population grows.2 In 2000, 13.1% of all Americans were aged 65 years and older. By 2050, that proportion will increase dramatically to 21.8%.3 Although some mental disorders can be treated with drugs and… Continue

Added by psychiatryRounds Psychiatry News on February 1, 2007 at 11:00pm — No Comments

Optimizing Individual Outcomes in Schizophrenia: Challenges and Opportunities

(PSYCHIATRIC TIMES) - Despite significant advances in our understanding of the nature of the disease and development of more effective treatments, schizophrenia remains one of the most challenging medical conditions of our time. In every decade of life, individuals with schizophrenia are twice as likely to die as those who do not have schizophrenia and, on average, those who have schizophrenia die 15 to 20 years sooner than the general population.



The significant social impairment… Continue

Added by psychiatryRounds Psychiatry News on February 1, 2007 at 11:00pm — No Comments

Assessing Statins for Alzheimer Disease: Conflicting Evidence

(PSYCHIATRIC TIMES) - he second report from the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial was recently published, along with several reviews of clinical and laboratory investigations of the statins, in a theme issue of Acta Neurologica Scandinavica. The accumulated data reflect the potential of the agents to affect the onset or course of Alzheimer disease (AD), with contradictory or insufficient evidence of treatment effect.



The first ADCLT report suggested… Continue

Added by psychiatryRounds Psychiatry News on February 1, 2007 at 10:30pm — No Comments

Biological Markers and the Future of Early Diagnosis and Treatment in Schizophrenia

(PSYCHIATRIC TIMES) - Early intervention is key in psychiatry because it may improve prognosis. This has been especially difficult with schizophrenia. There is a strong basis for schizophrenia as a neurodevelopmental disorder, and the illness may result from several factors: genetic inheritance, disturbance of the in utero environment, and exposure to biological and psychosocial factors in infancy and early childhood, to name a few. Early environmental risk factors for schizophrenia include… Continue

Added by psychiatryRounds Psychiatry News on February 1, 2007 at 10:30pm — No Comments

The Metabolic Syndrome and Schizophrenia: Clinical Research Update

(PSYCHIATRIC TIMES) - Death as a result of cardiovascular (CV) complications represents the leading natural cause of excess mortality in patients with schizophrenia.1 While lifestyle variables such as high rates of smoking, poor dietary habits, and inactivity contribute to CV disease, research has also focused on a cluster of abnormalities that define metabolic syndrome (Table 1). Although considerable debate exists about whether a diagnosis of metabolic syndrome confers added CV risk compared… Continue

Added by psychiatryRounds Psychiatry News on February 1, 2007 at 10:30pm — No Comments

Risk Factors for Suicide in Patients With Schizophrenia

(PSYCHIATRIC TIMES) - It has long been known that persons with schizophrenia are at high risk for attempted and completed suicide. With estimates of about 5% to 15% for completed suicide1,2 and 20% to 40% for attempted suicide,3-6 the recent increase in attention to this concern is promising. Most studies have involved reviews of patient charts and reviews of psychiatric and death registries, which limits our understanding of risk factors, warning signs, and potential interventions. More… Continue

Added by psychiatryRounds Psychiatry News on February 1, 2007 at 10:30pm — No Comments

Childhood-Onset Schizophrenia: Diagnostic and Treatment Challenges

(PSYCHIATRIC TIMES) - As a consequence of its premorbid impairments, insidious onset, and relative treatment resistance, childhood-onset schizophrenia (COS) presents clinicians with a number of diagnostic dilemmas and treatment challenges. COS occurs in fewer than 1 in 10,000 children1 and fewer than 1% of patients with schizophrenia receive this diagnosis in childhood.2 The ages and rates at onset are similar in boys and girls.3



Characterized by the onset of psychosis before the age… Continue

Added by psychiatryRounds Psychiatry News on February 1, 2007 at 10:30pm — No Comments

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