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January 2007 News and Blog Posts (27)

Celexa Effective Against Depression with Heart Patients

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that when depression accompanies coronary artery disease, two SSRI antidepressants, Celexa and Zoloft, now show evidence of efficacy,



o Point out that a large randomized clinical trial is still necessary to determine whether treatment of depression in these patients has beneficial effects on the occurrence of cardiovascular events.



MONTREAL, Jan 23 -- The selective serotonin… Continue

Added by psychiatryRounds Psychiatry News on January 23, 2007 at 11:00pm — No Comments

Celexa Effective Against Depression with Heart Patients

(PSYCHIATRIC TIMES) - MONTREAL, Jan 23 -- The selective serotonin reuptake inhibitor (SSRI) Celexa (citalopram) appears effective in treating depression among patients with coronary artery disease, researchers here found.



Celexa yielded a 31% greater response rate than placebo, but the addition of interpersonal psychotherapy did not increase the benefit, said François Lespérance, M.D., of the University of Montréal, and colleagues, in the Jan. 24-31 issue of the Journal of the… Continue

Added by psychiatryRounds Psychiatry News on January 23, 2007 at 11:00pm — No Comments

Alzheimer's Vaccine Makes Strides by Patch Delivery

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that the accumulation of beta amyloid in the brain is thought to be a key factor in the development of Alzheimer's Disease.



o Note that several animal studies have shown that a vaccine against beta amyloid can reduce the accumulation, but a human study had to be halted because of dangerous side effects.



o Explain that this study suggests that a transcutaneous vaccine might… Continue

Added by psychiatryRounds Psychiatry News on January 23, 2007 at 10:30pm — No Comments

Alzheimer's Vaccine Makes Strides by Patch Delivery

(PSYCHIATRIC TIMES) - TAMPA, Fla., Jan. 23 -- A safe and effective vaccine against Alzheimer's disease may be back on track, this time by transdermal patch delivery, according to researchers here.



In experimental mice, transcutaneous vaccine administration with beta amyloid peptide sharply reduced the levels of beta amyloid proteins that muddy the brain in Alzheimer's, found Jun Tan, Ph.D., M.D., of the University of South Florida.



There was saw no sign of the worrisome… Continue

Added by psychiatryRounds Psychiatry News on January 23, 2007 at 10:30pm — No Comments

The New Year in Psychiatry

(PSYCHIATRIC TIMES) - MedPage Today Action Points



NEW YORK, Jan. 18 -- Gauging the winds of medical advances is an iffy proposition at best, but for psychiatrists the new year is likely to bring much-anticipated data on the safety and efficacy of antipsychotic and bipolar medications in children and adolescents.



With pediatric safety and efficacy data lacking for most drugs used to treat schizophrenia and bipolar disorder, use of these drugs in pediatric patients is more… Continue

Added by psychiatryRounds Psychiatry News on January 18, 2007 at 4:00am — No Comments

The New Year in Psychiatry

(PSYCHIATRIC TIMES) - NEW YORK, Jan. 18 -- Gauging the winds of medical advances is an iffy proposition at best, but for psychiatrists the new year is likely to bring much-anticipated data on the safety and efficacy of antipsychotic and bipolar medications in children and adolescents.



With pediatric safety and efficacy data lacking for most drugs used to treat schizophrenia and bipolar disorder, use of these drugs in pediatric patients is more off-label than on-label, noted Christoph… Continue

Added by psychiatryRounds Psychiatry News on January 18, 2007 at 4:00am — No Comments

Alzheimer's Genetic Suspect Comes Forward

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that an international team of researchers has identified a gene that may play a role in the pathogenesis of late-onset Alzheimer's disease, the most common form of the disorder.



o Explain that this finding needs to be confirmed, but could form the basis for diagnostic or therapeutic approaches to Alzheimer's disease in the future.



TORONTO, Jan. 15 -- A second gene as a possible… Continue

Added by psychiatryRounds Psychiatry News on January 15, 2007 at 11:00pm — No Comments

Alzheimer's Genetic Suspect Comes Forward

(PSYCHIATRIC TIMES) - TORONTO, Jan. 15 -- A second gene as a possible accessory in the development of late-onset Alzheimer's disease has been identified by an international team of researchers.



Inherited variants of the gene, called SORL1, short for sortilin-related receptor 1, may be indirectly involved in the abnormal production and deposition in the brain of beta-amyloid plaques, reported the researchers online in Nature Genetics.



"Taken together, our results suggest… Continue

Added by psychiatryRounds Psychiatry News on January 15, 2007 at 10:30pm — No Comments

Migraine and Depression Mix with Somatic Symptoms

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that this study suggests women with chronic headaches are more likely to also suffer from depression and other physical symptoms.



o Explain to patients that this cross-sectional study does not establish a causal relationship among headaches, depression, and somatic complaints.



TOLEDO, Ohio, Jan. 9 -- Migraine sufferers often have more than a headache, according to investigators… Continue

Added by psychiatryRounds Psychiatry News on January 9, 2007 at 11:00pm — No Comments

Folate Weakly Linked to Reduced Alzheimer's Disease Risk

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to patients who ask that this observational study does not by itself support increasing folate intake to prevent Alzheimer's.



o Inform interested patients that this study was conducted in a primarily African American and Hispanic female population.



NEW YORK, Jan. 8 -- Folate appears associated with a lower risk of Alzheimer's disease, although the relationship is tenuous, according to an observational… Continue

Added by psychiatryRounds Psychiatry News on January 8, 2007 at 11:00pm — No Comments

Folate Weakly Linked to Reduced Alzheimer's Disease Risk

(PSYCHIATRIC TIMES) - NEW YORK, Jan. 8 -- Folate appears associated with a lower risk of Alzheimer's disease, although the relationship is tenuous, according to an observational study here.



In the study of older, predominantly African-American and Hispanic women, a 50% reduction in the risk of Alzheimer's was found only for those consuming the highest amount of folate (488 µg or more), and only after adjusting for vitamin B intake, said José A. Luchsinger, M.D., of Columbia… Continue

Added by psychiatryRounds Psychiatry News on January 8, 2007 at 11:00pm — No Comments

MRI reveals early brain changes linked to schizophrenia

(PSYCHIATRIC TIMES) - Findings by a team in Scotland have opened the way to an accurate predictive test that might help prevent the onset of schizophrenia. MR scans have revealed changes in brain tissue in a small group of individuals before they developed schizophrenia.



The research, led by Dr. Dominic Jobs of the University of Edinburgh, suggests that looking at changes in brain structure over time could help doctors to predict whether a person who has a family history of… Continue

Added by psychiatryRounds Psychiatry News on January 8, 2007 at 11:00pm — No Comments

The Year in Neurology

(PSYCHIATRIC TIMES) - BOSTON, Jan. 8 -- Clinical and research developments in neurology in 2006 seemed to be as much about prevention as treatment.



Among the highlights were the return to the market of Tysabri (natalizumab) for multiple sclerosis, a treatment for Parkinson's dementia, the ongoing struggles to understand the causes and treatment of autism spectrum disorders, and new evidence about the influence of diet in preventing cognitive decline.



For full article,… Continue

Added by psychiatryRounds Psychiatry News on January 8, 2007 at 8:30pm — No Comments

Glass Half Empty for Binge-Drinking Women

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that this study may help explain why the results of some prior studies looking at a link between alcohol intake and depression have conflicted.



LONDON, Ontario, Jan. 4 -- Binge drinking appears linked to depression, particularly among women, according to a large survey.



Among women who typically consumed seven or more standard alcoholic beverages on an occasion, 24.5% met… Continue

Added by psychiatryRounds Psychiatry News on January 4, 2007 at 11:00pm — No Comments

Sleep Upset Paired with Depression in Kids

(PSYCHIATRIC TIMES) - MedPage Today Action Points



o Explain to interested patients that depression and sleep disturbances are often seen together in adults, and this study suggests that same is true for children.



o Explain that more serious sleep disturbances among children in the study were shown to be associated with more severe symptoms.



PITTSBURGH, Jan. 2 -- Poor sleep is a frequent companion of depression in children, according to researchers… Continue

Added by psychiatryRounds Psychiatry News on January 2, 2007 at 11:00pm — No Comments

Sleep Upset Paired with Depression in Kids

(PSYCHIATRIC TIMES) - PITTSBURGH, Jan. 2 -- Poor sleep is a frequent companion of depression in children, according to researchers here.



Just like in adults, sleep disturbances and depression go hand in hand in children, reported Xianchen Liu, M.D., Ph.D., of the University of Pittsburgh, in the Jan. 1 issue of Sleep.



In research conducted as part of a larger study in Hungary, Dr. Liu and colleagues found that 72.7% of 553 children with a current depressive episode also… Continue

Added by psychiatryRounds Psychiatry News on January 2, 2007 at 11:00pm — No Comments

Depression in Epilepsy: Chipping Away at Obstacles to Diagnosis and Care

(PSYCHIATRIC TIMES) - Clinical depression is an increasingly well-recognized sequela of epilepsy (see "Optimizing Treatment of Seizures by Addressing Psychiatric Comorbidities," Applied Neurology, August 2006, pages 41-42). Questions are therefore surfacing as to whether patients with epilepsy are being adequately identified and treated.



Several poster sessions were presented on this topic at the annual meeting of the American Epilepsy Society, which took place December 1 to 5 in San… Continue

Added by psychiatryRounds Psychiatry News on January 1, 2007 at 11:00pm — No Comments

PET shows link between endorphins, depression

(PSYCHIATRIC TIMES) - Researchers have found more evidence that depression has its roots in specific alterations within the brain, particularly in the endorphin system that is a central part of the brain's natural pain and stress reduction capability.



Susan Kennedy, Ph.D., and colleagues at the University of Michigan Molecular and Behavioral Neuroscience Institute evaluated 28 women, 14 with major depression, and 14 healthy controls. Subjects were asked to recall a sad life event… Continue

Added by psychiatryRounds Psychiatry News on January 1, 2007 at 11:00pm — No Comments

Schizophrenia and Substance Abuse: Is There a Role for Atypical Antipsychotics?

(PSYCHIATRIC TIMES) - The prevalence of substance use disorders in patients with schizophrenia is greater than the rate observed in the general population,1 with a dramatic increase since the 1970s.2



Several theories exist to explain the high rate of comorbidity. The "self-medication" hypothesis3 suggests that persons may abuse substances to treat underlying psychotic symptoms or adverse effects of medications commonly used to treat schizophrenia.4,5 Other hypotheses include the… Continue

Added by psychiatryRounds Psychiatry News on January 1, 2007 at 11:00pm — No Comments

Self-Hypnosis Reduces Anxiety During Breast Biopsy

(PSYCHIATRIC TIMES) - BOSTON—A mind-body technique known as self-hypnotic relaxation performed during certain medical procedures significantly reduces pain, anxiety, drug use, and complications, Elvira V. Lang, MD, of Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, said in her keynote address at the Society for Integrative Oncology's Third International Conference.



Even though general anesthesia is usually not required for minimally invasive procedures,… Continue

Added by psychiatryRounds Psychiatry News on January 1, 2007 at 5:30am — No Comments

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